Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors

  • Duraid Al-Amily College of Pharmacy- University of Baghdad
  • Mohammed H. Mohammed
Keywords: primary amides, HDACIs, adipic monoanilide amide, pimelic monoanilide amide

Abstract

Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.

Published
2019-12-23