Correlation between Seminal Fructosamine and Glycosylation Gap and Some Sex Hormones in the Young Infertile Male in Mosul City
DOI:
https://doi.org/10.31351/vol31iss1pp293-297Keywords:
infertility, glycosylation, fructosamine, HbA1c and glycosylation gapAbstract
Infertility represents a growing health problem in Mosul city and worldwide. Infertility defined as a failure to induce pregnancy after unprotected sexual intercourse for more than 12 months. Infertility in male is a multifactorial complex pathology that leads to different types of problems. This work try to explore the correlation between glycosylation gap and seminal fructosamine and another parameter in the young male patient in Mosul city. The study included 50 subjects with age range 19-29 year with BMI 18-26. The infertility group include 25 patients newly diagnosed with infertility before starting any treatment; have no infection and no structural abnormality. The control group included 25 healthy subjects. HbA1c, fructosamine, Serum and seminal Testosterone, estradiol and Testosterone/ estradiol. Plasma trace element as K, Mg and Zn also measured. There was a significant elevation in the glycosylation profile in the infertile male in compare to control (p<0.05). There was a significant elevation in glycosylation gap in the infertile group (p<0.01). Testosterone and Testosterone/ Estradiol ratio significantly reduced in the infertile group in comparison to control group (p< 0.0004 and 0.0002 respectively). Serum and Seminal plasma Testosterone/ Estradiol ratio showed no significant changes between the two groups (p>0.05). In conclusion, there was a significant positive correlation seminal plasma fructosamine and glycosylation gap in infertile male group.
References
Deyhoul N, Mohamaddoost T, Hosseini M. Infertility-related risk factors: A systematic review. Int J Women’s Heal Reprod Sci. 2017;5(1):24-29. doi:10.15296/ijwhr.2017.05
Barratt CLR, Björndahl L, De Jonge CJ, Lamb DJ, Martini FO, McLachlan R, et al. The diagnosis of male infertility: An analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Hum Reprod Update. 2017;23(6):660-680. doi:10.1093/humupd/dmx021
Drabovich AP, Saraon P, Jarvi K, Diamandis EP. Seminal plasma as a diagnostic fluid for male reproductive system disorders. Nat Rev Urol. 2014;11(5):278-288. doi:10.1038/nrurol.2014.74
Janiszewska E, Kratz EM. Could the glycosylation analysis of seminal plasma clusterin become a novel male infertility biomarker? Mol Reprod Dev. 2020;87(5):515-524. doi:10.1002/mrd.23340
Cheon YP, Kim CH. Impact of glycosylation on the unimpaired functions of the sperm. Clin Exp Reprod Med. 2015;42(3):77-85. doi:10.5653/cerm.2015.42.3.77
Tecle E, Gagneux P. Sugar-coated sperm: Unraveling the functions of the mammalian sperm glycocalyx. Mol Reprod Dev. 2015;82(9):635-650. doi:10.1002/mrd.22500
Olejnik B, Kratz EM, Zimmer M, Ferens-Sieczkowska M. Glycoprotein fucosylation is increased in seminal plasma of subfertile men. Asian J Androl. 2015;17(2):274-280. doi:10.4103/1008-682X.138187
Johnson J, Flores MG, Rosa J, Han C, Salvi A M, DeMali KA, et al. The High Content of Fructose in Human Semen Competitively Inhibits Broad and Potent Antivirals That Target High-Mannose Glycans. J Virol. 2020;94(9):1-22. doi:10.1128/jvi.01749-19
Vitku J, Kolatorova L, Hampl R. Occurrence and reproductive roles of hormones in seminal plasma. Basic Clin Androl. 2017;27(1):1-12. doi:10.1186/s12610-017-0062-y
Salama N, Blgozah S. Serum estradiol levels in infertile men with non-obstructive azoospermia. Ther Adv Reprod Heal. 2020;14:1-11. doi:10.1177/2633494120928342
Palani AF, Alshatteri AHA. Impact of Trace Elements in the Seminal Plasma on Sperm Quality in Infertile Men. Zanco J Pure Appl Sci. 2017;29(s4). doi:10.21271/zjpas.29.s4.18
Bissé E, Abraham EC. New less temperature-sensitive microchromatographic method for the separation and quantitation of glycosylated hemoglobins using a non-cyanide buffer system. J Chromatogr B Biomed Sci Appl. 1985;344(C):81-91. doi:10.1016/S0378-4347(00)82009-5
Ahmed MA. Glycosylation gap in a group obese subjects. Iraq J Pharm 2013;13(2).
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)
This work is licensed under a Creative Commons Attribution 4.0 International License.
