Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives

  • Omeed M. Hassan
  • Susan W. Sarsam
Keywords: : Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method.

Abstract

Three new hydrazone derivatives of Etodolac were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy, and 1HNMR analysis. The synthesis of the target (P1-P3) compounds was accomplished following multistep reaction procedures. The synthesized target compounds were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac).

Published
2019-06-09