Synthesis, Characterization and Antibacterial Evaluation of Some Coumarin Derivatives

Authors

  • Tariq T. Abduljabbar University of baghdad
  • Mohammed K. Hadi

DOI:

https://doi.org/10.31351/vol30iss1pp249-257

Keywords:

Coumarin, hydrazones, amide, antibacterial, well diffusion method.

Abstract

Coumarin derivatives have shown different biological activities, such as antifungal, antibacterial   antiinflammatory, and antioxidant activities, besides antibiotic resistance modulating effects, and anti-HIV, hepatoprotective, and antitumor effect. So, new coumarin derivatives (hydrazones and an amide) were synthesized through multisteps reactions. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis. The compounds then evaluated for their anti-bacterial activity by means of well-diffusion method against two gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae) and two gram-negative bacteria  (E.coli and Pseudomonas aeruginosa). The highest activity was demonstrate by compound k2 which found to be highly active against pseudomonas aeruginosa.

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Published

2021-06-19

How to Cite

1.
T. Abduljabbar T, K. Hadi M. Synthesis, Characterization and Antibacterial Evaluation of Some Coumarin Derivatives. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2021 Jun. 19 [cited 2024 Nov. 5];30(1):249-57. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1231