The Pathological Mechanisms of Obesity-Related Glomerulopathy: A review article

Authors

  • Ali A. Kasim College of Pharmacy/ University of Baghdad
  • Ahmed H. Ataimish

DOI:

https://doi.org/10.31351/vol30iss1pp22-28

Keywords:

Obesity-related glomerulopathy, Renin-angiotensin-aldosterone system, Insulin resistance

Abstract

The rising prevalence of obesity-related glomerulopathy (ORG) occurs in accordance with the rising prevalence of obesity worldwide. Clinically ORG is manifested by slowly progressing microalbuminuria that may develop to clinically evident proteinuria. Pathological characteristics of ORG include glomerular hypertrophy in the presence or absence of focal segmental glomerulosclerosis (FSGS). ORG can develop into clinically overt chronic renal insufficiency or even end-stage kidney disease. This article reviews the most important mechanisms for the development of ORG; that are abnormal renal hemodynamics, stimulation of renin-angiotensin-aldosterone system (RAAS), impairment of insulin sensetivity, ectopic lipid deposition, adipose tissue cytokine disorder and local renal micro-inflammation.

 

Received: 27/ 9 /2020

Accepted: 14/ 11/2020

How to Cite

1.
Kasim AA, Ataimish AH. The Pathological Mechanisms of Obesity-Related Glomerulopathy: A review article. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2021 Jun. 15 [cited 2024 Dec. 19];30(1):22-8. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1234

Publication Dates

Downloads

Published

2021-06-15

Issue

Vol. 30 No. 1 (2021): Iraqi J Pharm Sci

Section

Review