Investigation of Lipid Polymer Hybrid Nanocarriers for Oral Felodipine Delivery: Formulation, Method, In-vitro and Ex-vivo Evaluation


  • Hayder Kadhim Drais 1Ministry of Health and Environment, Babil Health Directorate
  • Ahmed Abbas Hussein



Lipid-polymer hybrid nanocarriers, Felodipine , Microwave based method, SESET., Lipid-polymer hybrid nanocarriers, Felodipine , Microwave based method, SESET




Keskinbora KH, Jameel MA. Nanotechnology Applications and Approaches in Medicine: A Review. J Nanosci Nanotechnol Res. 2018; 2: 2:6

Vishwakarma N, Jain A, Sharma R, et al. Lipid-Based Nanocarriers for Lymphatic Transportation. AAPS Pharm SciTech. 2019 Jan;20(2):83. DOI: 10.1208/s12249-019-1293-3.

Mandhar Piyush, G. Joshi. "Development of Sustained Release Drug Delivery System: A Review.” 2015.

Siddartha Venkata Talluri, Gowthamarajan Kuppusamy, Veera Venkata

Satyanarayana Reddy Karri, Shashank Tummala, SubbaRao V. Madhunapantula. Lipid-based

nanocarriers for breast cancer treatment – a comprehensive review. Drug Delivery. 2016; 23:4. 1291-1305, DOI: 10.3109/10717544.2015.1092183

Westesen K, Siekmann B. Biodegradable colloidal drug carrier systems based on solid lipids. Drugs Pharmaceut Sci.1996; 73:213–58.

Yaghmur A, Glatter O. Characterization and potential applications of nanostructured aqueous dispersions. Adv Colloid Interface Sci. 2009; 147:333–42.

Cheow W S, Hadinoto K. Factors affecting drug encapsulation and stability of lipid–polymer hybrid nanoparticles. Colloids Surf. B Biointerfaces. 2011; 85: 214–20.

Wu X Y. Strategies for optimizing polymer–lipid hybrid nanoparticle-mediated drug delivery. Expert Opin. Drug Deliv. 2016; 5: 609–12.

Hadinoto K, Sundaresan A, Cheow WS. Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review. Eur J Pharm Biopharm. 2013;.85:427–43.

Drais H K, Hussein A A. Design and Preparation Lipid Polymer Hybrid Nanocarrier as Pulmonary Dispersion System Using a Novel Microwave Method. Research Journal of Pharmacy and Technology.2021; 14:1233-7.

Zhi W, Wang L, Hu X. Recent advances in the effects of microwave radiation on brains. Military Med Res. 2017; 4: 29.

Roer T.G. Microwave Electronic Devices. Springer Science and Business Media. 2012; 1–12.

Nava-Arzaluz, M. G. et al. “Single emulsion-solvent evaporation technique and modifications for the preparation of pharmaceutical polymeric nanoparticles.” Recent patents on drug delivery & formulation. 2012; 6(3): 209-23.

Drais Hayder Kadhim and Hussein Ahmed Abbas. Formulation and evaluation lipid polymer hybrid nanocarriers using a new innovative microwaves-based method. International Journal of Pharmaceutical Research. 2020;12 (4):1264-69.

Bershteyn A, Chaparro J, Yau R, et al. Polymer-supported lipid shells, onions, and flowers. Soft Matter. 2008;4(9):1787–91.

Mukherjee A, Waters A. K, Kalyan P, Achrol A S, Kesari, S, Yenugonda V M. Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives. International journal of nanomedicine. 2019; 14: 1937– 52.

Dave Vivek, Tak Kajal, Sohgaura Amit, Gupta Ashish, Sadhu Veera, Reddy Kakarla. Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications. Journal of Microbiological Methods. 2019.

Zhou J, Zhou D. Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers. Drug Design, Development and Therapy. 2015; 9: 5269 - 75.

Vázquez-Blanco S, González-Freire L, Dávila-Pousa MC, Crespo-Diz C. pH determination as a quality standard for the elaboration of oral liquid compounding formula. Farm Hosp. 2018; 42(6):221- 7. doi: 10.7399/fh.10932. PMID: 30381041.

Srilatha R, Aparna C, Srinivas Prathima, Sadanandam M. Formulation evaluation and characterization of glipizide nanoemulsion. Asian journal of pharmaceutical and clinical research. 2013;6(2).66-71.

D'Souza Susan. A Review of In Vitro Drug Release Test Methods for Nano-Sized Dosage Forms. Advances in Pharmaceutics. 2014: 1-12.

Joshi M, Pathak S, Sharma S, Patravale V. Design and in vivo pharmacodynamic evaluation of nanostructured lipid carriers for parenteral delivery of artemether: Nanoject. International journal of pharmaceutics. 2008; 364 (1): 119-26 .

Mohima Tania, Dewan Irin, Islam S. Mashraful, Rana Sohel, Hossain Alamgir. Encapsulation of zidovudine in different cellulosic acrylic and compatibility studies. International Journal of Pharmacy and Pharmaceutical Sciences. 2015; 7(1):487-95.

Ramakrishna S, Mihira V, Vyshnavi K Raja, Ranjith V. Design and evaluation of drug release kinetics of meloxicam matrix tablet. International Journal of Current Pharmaceutical Research. 2012;4(1):90-9.

Attari Z, Bhandari A, Jagadish P C, Lewis S. Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology, Saudi Pharmaceutical Journal 2015. do i. org / 10 .1016 / j .jsps .2015 .03.008

Abed Haithem N, Hussein H. “Ex-vivo Ex-Vivo Absorption Study of a Novel Dabigatran Etexilate Loaded Nanostructured Lipid Carrier Using Non-Everted Intestinal Sac Model. Iraqi Journal of Pharmaceutical Sciences. 2019;28(2):37-45.

Anarjan N, Jafarizadeh-Malmiri H, Nehdi IA, Sbihi HM, Al-Resayes SI, Tan CP. Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique. Int J Nanomedicine. 2015;10:1109-18. doi:10.2147/IJN.S72835

Sawant K, Dodiya S. Recent Advances and Patents on solid lipid nanoparticles. Recent Pat Drug Deliv Formul. 2008; 2:120- 35.

Klang M, McLymont V, Ng N. Osmolality, pH, and compatibility of selected oral liquid medications with an enteral nutrition product. JPEN J Parenter Enteral Nutr. 2013;37(5):689-94. doi:10.1177/0148607112471560

Bali V, Ali M, Ali J. Study of surfactant combinations and development of a novel nanoemulsion for minimizing variations in bioavailability of ezetimibe. Colloids Surf B Biointerfaces 2010;76:410-20.

Mandal B, Mittal NK, Balabathula P, et al. Development and in vitro evaluation of core-shell type lipid–polymer hybrid nanoparticles for the delivery of erlotinib in non-small cell lung cancer. Eur J Pharm Sci . 2016; 81:162–71.

Chaudhary Amity, Nagaich Upendra, Gulati Neha, Khosa V K, R L Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications. Journal of Advanced Pharmacy Education & Research. 2012;2(1):32-67.

Khan MM, Madni A, Torchilin V, et al. Lipid-chitosan hybrid nanoparticles for controlled delivery of cisplatin. Drug Deliv. 2019; 26(1):765-72. doi:10.1080/10717544.2019.1642420