The Ameliorative Effect of Fimasartan against Methotrexate-Induced Nephrotoxicity in Rats

Authors

  • Maryam Rasheed Abd University of Baghdad-College of Pharmacy
  • Ali Faris Hassan

DOI:

https://doi.org/10.31351/vol31iss1pp87-94

Abstract

Drug-induced acute kidney injury is a serious disorder. Oxidative stress has a key role in its initiation and progression. In this study, the possible ameliorative effect of fimasartan against methotrexate-induced nephrotoxicity was investigated in comparison with α-tocopherol in rats. Wistar rats were allocated into six groups and treated as follows: group Ӏ received water on a daily basis for 8 successive days; group ӀӀ received methotrexate (20 mg/kg) on day 1, followed by water for 7 successive days; group ӀӀӀ received fimasartan (3 mg/kg/day) for 7 successive days; group IV received α-tocopherol (1 g/kg/day) for 7 successive days; group V received methotrexate (20 mg/kg) on day 1, followed by fimasartan (3 mg/kg/day) for 7 successive days; and group VI received methotrexate (20 mg/kg) on day 1, followed by α-tocopherol (1 g/kg/day) for 7 successive days. Finally, after euthanization of each animal by diethyl ether, the samples were collected for analysis. Administration of fimasartan and α-tocopherol resulted in a significant decline in serum creatinine and urea, a significant reduction of renal malondialdehyde, and a significant elevation of renal superoxide dismutase-1 compared to the methotrexate-treated rats. In conclusion, fimasartan has ameliorative effects, comparable to those of α-tocopherol, on methotrexate-induced nephrotoxicity in rats. 

References

Soares S, C R Souza L, T Cronin M, M Waaga-Gasser A, F Grossi M, R Franco G, et al. Biomarkers and in vitro strategies for nephrotoxicity and renal disease assessment. Nephrol Ren Dis. 2020;5(1):1–14.

Darmon M, Joannidis M, Schetz M. Focus on critical care nephrology. Intensive Care Med. 2019;45(9):1288–91.

Soares S, C R Souza L, T Cronin M, M Waaga-Gasser A, F Grossi M, R Franco G, et al. Biomarkers and in vitro strategies for nephrotoxicity and renal disease assessment. Nephrol Ren Dis. 2020;5(1):1–14.

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Published

2022-06-12