Ameliorative Effect of Galium Verum (Rubiaceae Family) Methanolic Extract on Folic Acid-induced Acute kidney Injury in Male Rats.
DOI:
https://doi.org/10.31351/vol32iss3pp14-24Keywords:
Galium verum; Acute kidney injury, Oxidative stress; Natural productAbstract
Background: Antioxidant, sedative, anticancer, and antibacterial properties are among the numerous pharmacological characteristics of Galium verum. Aim: The primary goal of this research was to investigate the therapeutic effects of G. verum extract against folic acid-induced acute kidney injury (AKI). Materials and methods: 18 male rats were assigned into three groups: Control, AKI, and G. verum. AKI was induced by a dose of folic acid (250 mg/kg, i.p.) while G. verum (250 mg/kg) was administrated for 7 consecutive days. Results: G. verum methanol extract contains flavonoids, anthraquinones, tannins, iridoids, triterpenes, steroids, phenols, and saponins, while it free of cardiac glycosides and alkaloids. G. verum extract significantly decreased levels of creatinine, urea, uric acid, sodium, chloride, potassium, microalbumin, malondialdehyde and nitric oxide while it increased creatinine clearance, glutathione reduced, and catalase levels. Meanwhile, histological examination of the kidney’s tissues revealed apparently normal structure. Conclusions: Underlying renal therapeutic mechanisms of G. verum action include a diuretic, antioxidant, and anti-inflammatory properties of G. verum extract resulting in improving kidney structure and enhance recovery of renal function.
How to Cite
Publication Dates
References
Saad DY, Farouk AE, Soliman AM, Mohamed AS, Khalil HA. Therapeutic Effect of Chitosan-Zinc Oxide Nanoparticles on Acute Kidney Injury Induced by Gentamicin in Wistar Rats. Current Nanomedicine. 2023;13(3):217 - 27.
Jiang M, Wei Q, Dong G, Komatsu M, Su Y, Dong Z. Autophagy in proximal tubules protects againstacute kidney injury. Kidney international. 2012;82(12):1271–12831271.
Mehta RL, Cerdá J, Burdmann EA, Tonelli M, García-García G, Jha V, et al. International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. The Lancet. 2015;385(9987):2616-43.
Lewington A, Kanagasundaram S. Renal association clinical practice guidelines on acute kidney injury. Nephron. 2011;118:c349.
Shahrbaf FG, Assadi F. Drug-induced renal disorders. Journal of renal injury prevention. 2015;4(3):57.
Heyman SN, Rosen S, Rosenberger C. Animal models of renal dysfunction: acute kidney injury. Expert opinion on drug discovery. 2009;4(6):629-41.
Naughton CA. Drug-induced nephrotoxicity. American family physician. 2008;78(6):743-50.
Miller JW. Folic acid. Encyclopedia of Human Nutrition: Elsevier Inc; 2012. p. 262-9.
Silva C, Keating E, Pinto E. The impact of folic acid supplementation on gestational and long term health: Critical temporal windows, benefits and risks. Porto biomedical journal. 2017;2(6):315-32.
Long DA, Price KL, Ioffe E, Gannon CM, Gnudi L, White KE, et al. Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney international. 2008;74(3):300-9.
Dai C, Kiss LP, Liu Y. Animal models of kidney diseases. Sourcebook of Models for Biomedical Research: Springer; 2008. p. 657-64.
Schmidt U, Torhorst J, Huguenin M, Dubach UC, Bieder I, Funk B. Acute Renal Failure after Folate: NaKATPase in Isolated Rat Renal Tubule: Ultramicrochemical and Clinical Studies. European journal of clinical investigation. 1973;3(3):169--78.
Gupta A, Puri V, Sharma R, Puri S. Folic acid induces acute renal failure (ARF) by enhancing renal prooxidant state. Experimental and Toxicologic Pathology. 2012;64(3):225-32.
Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. The American journal of clinical nutrition. 1993;57(5):715S--25S.
Pavlakou P, Liakopoulos V, Eleftheriadis T, Mitsis M, Dounousi E. Oxidative stress and acute kidney injury in critical illness: pathophysiologic mechanisms—biomarkers—interventions, and future perspectives. Oxidative medicine and cellular longevity. 2017;2017.
Kumar D, Singla SK, Puri V, Puri S. The restrained expression of NF-kB in renal tissue ameliorates folic acid induced acute kidney injury in mice. PLoS One. 2015;10(1):e115947.
Rizwan F, Yesmine S, Banu SG, Chowdhury IA, Hasan R, Chatterjee TK. Renoprotective effects of stevia (Stevia rebaudiana Bertoni), amlodipine, valsartan, and losartan in gentamycin-induced nephrotoxicity in the rat model: Biochemical, hematological and histological approaches. Toxicology reports. 2019; 6:683-91.
Sadek SA, Hassanein SS, Mohamed AS, Soliman AM, Fahmy SR. Echinochrome pigment extracted from sea urchin suppress the bacterial activity, inflammation, nociception, and oxidative stress resulted in the inhibition of renal injury in septic rats. Journal of food biochemistry. 2021;2021: e13729. doi:10.1111/jfbc.
Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, et al. Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proceedings of the National Academy of Sciences. 2010;107(6):2699-704.
El-Sisi AA, Fahmy SR, El-Desouky MA, El-Tawil O, Mohamed AS, El-Sherif AA. Protective roles of novel thiosemicarbazone derivatives on hepatotoxicity and nephrotoxicity induced by cadmium chloride in rats. Acta Poloniae Pharmaceutica - Drug Research. 2021;78(2):193–203.
Al Shawoush AM, Said RS, Hassan FE, Ali SB, Mohamed AS, Elbatran MM. Therapeutic effect of Nigella sativa extract on folic acid-induced acute hepatorenal injury: influences and underlying mechanisms. Current Topics in Pharmacology. 2022; 26:49 - 55.
Schmidt M, Scholz CJ, Gavril GL, Otto C, Polednik C, Roller J, et al. Effect of Galium verum aqueous extract on growth, motility and gene expression in drug-sensitive and-resistant laryngeal carcinoma cell lines. International journal of oncology. 2014;44(3):745-60.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)
This work is licensed under a Creative Commons Attribution 4.0 International License.
