Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation

Authors

Viviane Annisa Universitas Gadjah Mada
Teuku Nanda Saifullah Sulaiman Universitas Gadjah Mada https://orcid.org/0000-0001-6733-0221
Akhmad Kharis Nugroho Universitas Gadjah Mada https://orcid.org/0000-0003-4277-5413
Agung Endro Nugroho Dept. Farmacology and toxicology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281 https://orcid.org/0000-0002-1785-4008
Roman Kutsyk

DOI:

https://doi.org/10.31351/vol31iss2pp150-159

Keywords:

Synergistic interactions, alginate, pectin, carrageenan, polymers viscosity

Abstract

Alginate is one of the natural biopolymers that is widely used for drug formulations, combination of alginate with other polymers, such as gum acacia, pectin, and carrageenan can increase mechanical strength, therefore, can reduce leakage of the encapsulated active pharmaceutical ingredient from the polymer matrix. Interaction of alginate and these polymers can occur via intermolecular hydrogen bonds causing synergism, which is determined from the viscosity of polymer mixture.

Alginate was combined with gum acacia/pectin/carrageenan in different blending ratios (100:0, 75:25, 50:50, 25:75, and 0:100) with and without addition of CaCl₂. The synergism effect is obtained from the design of experimental (DoE), and calculation the percentage value of viscosity deviation viscosity synergism index, then the strength of gel was analyzed. The interaction between two polymers was observed using FTIR spectroscopy.

In distilled water, the synergistic effect was found in the combination of alginate-carrageenan at ratios 25:75 and 50:50. Otherwise, in CaCl₂solution, synergistic effect appears in alginate-gum acacia (75:25), alginate-pectin (50:50 and 75:25), and alginate-carrageenan (50:50 and 75:25). The synergistic effect and strength of gel polymers increased, with the addition of CaCl₂.

How to Cite

Annisa V, Sulaiman TNS, Nugroho AK, Nugroho AE, Roman Kutsyk. Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2022 Dec. 24 [cited 2024 Dec. 19];31(2):150-9. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1572

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Published

2022-12-24

Issue

Vol. 31 No. 2 (2022): Iraqi J Pharm Sci

Section

Article

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This work is licensed under a Creative Commons Attribution 4.0 International License.