Ameliorative Effects of the Aqueous Extract of Allium porrum (Wild Leek) against Cisplatin-Induced Nephrotoxicity in Rabbits

Authors

  • HS Mohammed
  • MHS Ahmida
  • MF Madi
  • A A Abdel-Gayoum

DOI:

https://doi.org/10.31351/vol30iss2pp177-184

Keywords:

Allium porrum, Cisplatin, Dyslipidemia, Nephrotoxicity, Wild Leek

Abstract

The aim of the present study was to investigate the nephroprotective, hypolipidemic and hypoglycemic effects of Allium porrum (leek) in rabbits with cisplatin nephrotoxicity. Forty adult male New Zealand rabbits were divided randomly into four groups (ten rabbits in each group) as follows: Group I: (negative control) (C) received oral daily dose of distilled water for 15 successive days. Groups II: (Leek) (L) received oral daily dose of aqueous leek extract (500mg/kg/day) for 15 successive days. Group III: (positive control) [cisplatin (CP)] received oral daily dose of distilled water for 15 successive days, and subsequently administered single dose of Cisplatin (3.5mg/kg/day) by intraperitoneal injection from day 10 for five days. Groups IV: (Leek and Cisplatin

Received: 12/1/2021

Accepted:24 /5 /2021

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Published

2021-12-11

Issue

Vol. 30 No. 2 (2021): Iraqi J Pharm Sci

Section

Article

How to Cite

1.
Mohammed H, Ahmida M, Madi M, Abdel-Gayoum AA. Ameliorative Effects of the Aqueous Extract of Allium porrum (Wild Leek) against Cisplatin-Induced Nephrotoxicity in Rabbits. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2021 Dec. 11 [cited 2024 Nov. 5];30(2):177-84. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1673