Study The Lung-Protective Effects of Riboflavin and Cyanocobalamin Against Lung Toxicity-Induced by Cyclophosphamide in Rats
DOI:
https://doi.org/10.31351/vol32iss1pp100-106Keywords:
cyclophosphamide, vitamin B2, vitamin B12, lung toxicityAbstract
Cyclophosphamide (CP) is a cytotoxic alkylating agent it's used associated with different side effects including lung toxicity. Vitamin B2 and vitamin B12 have lung-protective effects. This study was designed to evaluate lung-protective effects of both vitamins against lung toxicity induced by cyclophosphamide. seventy healthy adult albino male and female rats divided into seven groups each group containing ten rats were used in the present study and treated for seven days. On day eight rats were sacrificed and serum was obtained for glutathione and total antioxidant capacity measurement and lung extracted for immunohistochemical study; both vitamins significantly (P<0.05) increased glutathione and total antioxidant capacity in comparison with group two and improve immunohistochemical changes in comparison with the group treated by cyclophosphamide only
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Ghanim WK. Evaluating the Effects of Different Doses of Vitamin B2 and Single Dose of Vitamin B12 Against Myelosuppression Induced by Cyclophosphamide in Experimental Rats. Iraqi Journal of Pharmaceutical Sciences (P-ISSN: 1683-3597, E-ISSN: 2521-3512). 2020;29(1):134-42.
Habibi E, Shokrzadeh M, Ahmadi A, Chabra A, Naghshvar F, Haghi-Aminjan H, et al. Pulmonoprotective action of Zataria multiflora ethanolic extract on cyclophosphamide-induced oxidative lung toxicity in mice. Chinese journal of integrative medicine. 2020;26(10):754-61.
El-Kashef DH. Role of venlafaxine in prevention of cyclophosphamide-induced lung toxicity and airway hyperactivity in rats. Environmental Toxicology and Pharmacology. 2018;58:70-6.
Suwannasom N, Kao I, Pruß A, Georgieva R, Bäumler H. Riboflavin: The health benefits of a forgotten natural vitamin. International Journal of Molecular Sciences. 2020;21(3):950.
Mielgo-Ayuso J, Aparicio-Ugarriza R, Olza J, Aranceta-Bartrina J, Gil Á, Ortega RM, et al. Dietary intake and food sources of niacin, riboflavin, thiamin and vitamin B6 in a representative sample of the Spanish population. The ANIBES study. Nutrients. 2018;10(7):846.
Liu S, Hu W, Wang Z, Chen T. Production of riboflavin and related cofactors by biotechnological processes. Microbial cell factories. 2020;19(1):1-16.
Balasubramaniam S, Christodoulou J, Rahman S. Disorders of riboflavin metabolism. Journal of inherited metabolic disease. 2019;42(4):608-19.
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Copyright (c) 2023 Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)
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