Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches
DOI:
https://doi.org/10.31351/vol32iss1pp147-155Keywords:
Keywords: ondansetron hydrochloride, transdermal patches, ethyl cellulose, propylene glycol, polyvinyl pyrrolidone.Abstract
This research aims to develop transdermal patches of Ondansetron hydrochloride (OSH) with different types of polymers, ethyl cellulose and, polyvinyl pyrrolidone k30 in a ratio (3:0.5,3:1,3:2,2:1,1:1) with propylene glycol 20%w/w as a plasticizer. Prepared transdermal patches were evaluated for physical properties. The compatibility between the drug and excipients was studied by Differential scanning calorimetry (DSC), where there is no interaction between the drug and polymers. From the statistical study, there is a statistical difference between all the prepared formulations p<0.05. In-vitro Release study of transdermal patches was performed by using a paddle over the disc. The release profile of OSH followed Korsmeyer - Peppas Model in P2, P4 formulations and, Higuchi Model in P1, P3, P5 formulations. The best formulation P6 carrying EC:PVP in ratio1:1 released 96.47% of ondansetron hydrochloride during 12 h. The release profile of P6 followed the Higuchi model and correlation coefficient (r2 = 0.9815)
References
Smith C, Smith M, Cunningham R, Davis S. Recent Advances in Antiemetics: New Formulations of 5-HT3 Receptor Antagonists in Adults. Cancer Nurs. 2020;43(4):E217–28.
Huddart R, Altman RB, Klein TE. PharmGKB summary: Ondansetron and tropisetron pathways, pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2019;29(4):91–7.
David SRN, Rajabalaya R, Zhia ES. Development and in vitro evaluation of self-adhesive matrix-type transdermal delivery system of ondansetron hydrochloride. Trop J Pharm Res. 2015;14(2):211–8.
Bhardwaj S, Bhatia S, Singh S. Transdermal Delivery of Ondansetron Hydrochloride in the management of Hyperemesis Gravidarum. Int J Pharma Sci Res. 2020;11(8):206–14.
Shayeda D, Ayesha N. Development of Tizanidine HCl transdermal patches: In-vitro and Ex-vivo characterization. J Drug Deliv Ther. 2019;9(1-s):295–300.
Saeedi M. A Review on Current Status and Future Potential of Transdermal Patches as a Promising Drug Delivery System. J Maz Univ Med Sci. 2019;29(17300596):164–75.
Ng LC, Gupta M. Transdermal drug delivery systems in diabetes management: A review. Asian J Pharm Sci [Internet]. 2020;15(1):13–25. Available from: https://doi.org/10.1016/j.ajps.2019.04.006
Sharma N, Sharma S, Kaushik R. Formulation and evaluation of lornoxicam transdermal patches using various permeation enhancers. Int J Drug Deliv Technol. 2019;9(4):597–607.
Al Hanbali OA, Khan HMS, Sarfraz M, Arafat M, Ijaz S, Hameed A. Transdermal patches: Design and current approaches to painless drug delivery. Acta Pharm. 2019;69(2):197–215.
Fathima F, Vijaya Kumar B, Suman Rudrangi SR, Vemula SK, Garrepally P, Chilukula S, et al. Formulation and evaluation of matrix-type Transdermal delivery system of Ondansetron hydrochloride using solvent casting technique. Res J Pharm Technol. 2011;4(5):806–14.
Yadav AV, Urade MN. Formulation and evaluation of chitosan based transdermal patches of lornoxicam for prolonged drug release and to study the effect of permeation enhancer. Indian J Pharm Educ Res. 2019;53(1):88–96.
Yousuf M, Ahmad M, Naeem M, Khan MK, Khan BA. Development and In Vitro Evaluation of Polymeric Responsive Release Matrix Type Transdermal Patches of Two Anti-asthmatic Drugs. Iran J Sci Technol Trans A Sci [Internet]. 2021;45(1):1–10. Available from: https://doi.org/10.1007/s40995-020-00985-2
Sateesh Kumar V. Formulation and Evaluation of Transdermal Films of Ondansetron Hydrochloride. MOJ Bioequivalence Bioavailab. 2017;3(4).
Mamatha J, Gadili S, Pallavi K. Formulation and Evaluation of Zidovudine Transdermal Patch using Permeation Enhancers. J Young Pharm. 2020;12(2s):s45–50.
Anod H V., Gupta NV, Gowda D V., Manohar M. Preparation and evaluation of simvastatin transdermal film. Int J Appl Pharm. 2018;10(5):235–8.
Patel R, Patel A, Prajapati B, Shinde G, Dharamsi A. Transdermal Drug Delivery Systems: a Mini Review. Int J Adv Res. 2018;6(5):891–900.
Akhlaq M, Arshad MS, Mudassir AM, Hussain A, Kucuk I, Haj-Ahmad R, et al. Formulation and evaluation of anti-rheumatic dexibuprofen transdermal patches: a quality-by-design approach. J Drug Target. 2016;24(7):603–12.
Agrahari S, Sharma A, Kumar S, Sharma A, Sagar MK. Formulation and Development of Transdermal Patches of Piroxicam. Asian J Pharm Res Dev. 2019;7(3):119–28.
Patel R, Patel A, Prajapati B, Shinde G, Dharamsi A. Transdermal Drug Delivery Systems: a Mini Review. Int J Adv Res. 2018;6(5):891–900.
Hashmat D, Shoaib MH, Ali FR, Siddiqui F. Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers. PLoS One [Internet]. 2020;15(2):1–23. Available from: http://dx.doi.org/10.1371/journal.pone.0228908
Mahajan NM, Zode GH, Mahapatra DK, Thakre S, Dumore N, Gangane PS. Formulation development and evaluation of transdermal patch of piroxicam for treating dysmenorrhoea. J Appl Pharm Sci. 2018;8(11):35–41.
Anilkumar A, Murthy TEGK, Rani AP. Formulation of ondansetron HCl matrix tablets with microenvironmental pH modifier for improved dissolution and bioavailability under hypochlorhydria. Asian J Pharm. 2016;10(3):188–97.
Mutalik S, Udupa N. Glibenclamide transdermal patches: Physicochemical, pharmacodynamic, and pharmacokinetic evaluations. J Pharm Sci. 2004;93(6):1577–94.
Paarakh MP, Jose PANI, Setty CM, Peter G V. Release Kinetics – Concepts and Applications. Int J Pharm Res Technol. 2019;8(1):12–20.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)
This work is licensed under a Creative Commons Attribution 4.0 International License.