The Effect of Molecular Imprinting on the Loading and Release of Poorly Water Soluble Drug in Hydrogel Gontact Lenses
Keywords:Contact lenses, Molecular imprinting, itraconazole, sustained release, ocular drug delivery
Therapeutic contact lenses TCLs is an approach used to enhance corneal residence time and reduce frequent instillation, which is a problem with eye drops. The problem with CLs is loading of hydrophobic drugs. In this research the CLs were prepared with molecular imprinting MI to enhance the loading of itraconazole, which is used as antifungal drug for fungal keratitis. CLs using different concentration of hydroxyethyl methacrylate HEMA and methacrylic acid MAA were prepared with and without MI using PEGDA (25 μL) and AIBN (37 mg) as crosslinker and initiator respectively. All the prepared CLs were clear and have good folding endurance. MICLs had significantly higher drug loading compared to conventional CLs. The release of itraconazole from MICLs was sustained compared to conventional CLs. The optimum formula chosen had 8% MAA due to maximum drug loading (1077 μg) compared to non-MI (288 μg) and sustained release for more than 24 h. MI was successfully utilized as a tool to enhance the loading of poorly water soluble drug into a hydrogel CL.
Ting DSJ, Galal M, Kulkarni B, Elalfy MS, Lake D, Hamada S, et al. Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011–2020: A 10-Year Study. Journal of Fungi. 2021;7(11):966.
Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW. The global incidence and diagnosis of fungal keratitis. he Lancet Infectious Diseases. 2020.
Al-Badriyeh D, Neoh CF, Stewart K, Kong DC. Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis. Clinical Ophthalmology. 2010;4:391.
Grassiri B, Zambito Y, Bernkop-Schnürch A. Strategies to prolong the residence time of drug delivery systems on ocular surface. Advances in colloid interface science. 2020:102342.
Al-shemmary II. In vitro MIC of itraconazole against different isolates of Candida albicans. Iraqi Journal of Pharmaceutical Sciences. 2011;20(1):33-7.
Jaiswal M, Kumar M, Pathak K. Zero order delivery of itraconazole via polymeric micelles incorporated in situ ocular gel for the management of fungal keratitis. Colloids Surfaces B: Biointerfaces. 2015;130:23-30.
Rashid AM, Abdal-Hammid SN. Formulation and characterization of itraconazole as nanosuspension dosage form for enhancement of solubility. Iraqi Journal of Pharmaceutical Sciences. 2019;28(2):124-33.
Copyright (c) 2023 Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)
This work is licensed under a Creative Commons Attribution 4.0 International License.