Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats
DOI:
https://doi.org/10.31351/vol32iss3pp128-133Keywords:
Diabetes, Enhydra fluctuans, Insulin resistance, Liver cells regenerationAbstract
Diabetes mellitus and insulin resistance cause harm to the liver. In this study, ameliorative effect of Enhydra fluctuans on liver damage in alloxan-induced diabetic rats were examined.
Thirty acclimatized male albino rats divided into six groups (n = 5). Normal rats were fed a standard diet (Group 1); diabetic rats were provided standard feed (Group 2); diabetic rats were fed standard feed and glibenclamide (Group 3); and diabetic rats were fed standard food and fractions of n-hexane E. fluctuans 57.03, 114.06, and 171.09 mg/kg, respectively (Group 4, 5 and 6). For 21 days, rats were fed the n-hexane fraction orally. On day 1 and day 21 of treatments, blood sugar levels were measured. The histophatology of the liver, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvate transaminase (SGPT) level were estimated.
At a dosage of 57.03 mg/kg was substantially (p < 0.05) beneficial in decreasing blood sugar and SGOT. The n-hexane fraction of E. fluctuans ameliorated liver damage in diabetic rats and avoided diabetes complications, according to our findings. As a result, E. fluctuans has a considerable amount of potential as a novel diabetic therapy.
Keywords: Diabetes, Enhydra fluctuans, Insulin resistance, Liver cells regeneration.
References
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019; 157(107843):1–10.
Internation Diabetes Federation. IDF Diabetes Atlas, 9th Edition. 9th ed. Dunia : IDF. Brussels, Belgium: International Diabetes Federation; 2019. 2 p.
Björkström K, Franzén S, Eliasson B, Miftaraj M, Gudbjörnsdottir S, Trolle-Lagerros Y, Svensson, A-M and Hagström H. Risk factors for severe liver disease in patients with type 2 diabetes. Clin Gastroenterol Hepatol. 2019; 17(13):2769-2775.e
Giannini EG, Testa R, Savarino V. Liver enzyme alteration: A guide for clinicians. Cmaj. 2005; 172(3):367–379.
Church RJ, Watkins PB. Serum biomarkers of drug-induced liver injury: Current status and future directions. J Dig Dis. 2019; 20(1):2–10.
Mohamed J, Nazratun Nafizah AH, Zariyantey AH, Budin SB. Mechanisms of diabetes-induced liver damage: The role of oxidative stress and inflammation. Sultan Qaboos Univ Med J. 2016; 16(2):e132–e141.
Mota M, Banini BA, Cazanave SC, Sanyal AJ. Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. Metabolism. 2016; 65(8):1049–1061.
Fagbohun OF, Awoniran PO, Babalola OO, Agboola FK, Msagati TAM. Changes in the biochemical, hematological and histopathological parameters in STZ-Induced diabetic rats and the ameliorative effect of Kigelia africana fruit extract. Heliyon. 2020; 6(5):e03989.
Sayeed SR, Ahmed H, Rahman S, Ahmad I. Polyherbal formulation for lowering blood glucose levels : Evaluation of a combination of Foeniculum vulgare and Brassica alba seeds. World J Pharm Sci. 2015; 4(10):79–85.
Delfita R, Dahelmi D, Tjong DH, Suhatri S. Protective effect of Enhydra fluctuans DC. aerial against insulitis in alloxan-induced diabetic rats. J Res Pharm. 2022; 26(1):180–188.
Delfita R, Tjong DH, Dahelmi D, Suhatri S. Hypoglycemic effects of Enhydra fluctuans aerial extract on alloxan-induced diabetic rats. J Phys Conf Ser. 2021; 1940(1):1–7.
Delfita R, Tjong DH, Dahelmi D, Suhatri S. Hypoglycemic effects of Enhydra fluctuans aerial extract on alloxan-induced diabetic rats. J Phys Conf Ser. 2021; 1940(1):012058.
Hasan MN, Sabrin F, Rokeya B, Khan MSH, Ahmed MU, Matondo A, Billah, MM and Akter, S. Glucose and lipid lowering effects of Enhydra fluctuans extract in cadmium treated normal and type-2 diabetic model rats. BMC Complement Altern Med. 2019; 19(1):1–10.
Deb S, Sharma U, Das S, Sahu R. Pharmacognostic Study and develoment of quality parameters of aerial part of plant Enhydra fluctuans Dc . J Pharm Chem Biol Sci. 2016; 4(2):198–207.
Ali R, Billah M, Hassan M, Rahman SM. Enhydra fluctuans Lour : A review. Res J Pharm Tech. 2013; 6(September):927–929.
Dua TK, Dewanjee S, Khanra R, Joardar S, Barma S. Cytoprotective and Antioxidant effects of an edible herb , Enhydra fluctuans Lour. (Asteraceae), against experimentally induced lead acetate intoxication. PLoS One. 2016; 11(2):1–21.
Sarkar P, Dalal A. Evaluation of antioxidant activity of Diplazium esculentum and Enhydra fluctuans of West Bengal. IOSR J Pharm Biol Sci. 2016; 11(6):45–50.
Hasballah K, Sarong M, Rusly R, Tantri K, Mulia VD. Acute toxicity and hepatotoxicity evaluation of methanol extract of root bark of Calotropis gigantea in rats. Dhaka Univ J Pharm Sci. 2018; 17(2):243–50.
Saha M, Rohani S, Rayhana N, Toma IJ, Rana S, Rahmatullah M. An herbal formulation containing Zingiber officinale rhizomes and Allium sativum cloves can increase oral glucose tolerance in mice. Biol Eng Med. 2017; 2(1):1–3.
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