Ameliorative Effect of Enhydra fluctuans on Liver Damage in Diabetic Rats
DOI:
https://doi.org/10.31351/vol32iss3pp128-133Keywords:
Diabetes, Enhydra fluctuans, Insulin resistance, Liver cells regenerationAbstract
Diabetes mellitus and insulin resistance cause harm to the liver. In this study, ameliorative effect of Enhydra fluctuans on liver damage in alloxan-induced diabetic rats were examined.
Thirty acclimatized male albino rats divided into six groups (n = 5). Normal rats were fed a standard diet (Group 1); diabetic rats were provided standard feed (Group 2); diabetic rats were fed standard feed and glibenclamide (Group 3); and diabetic rats were fed standard food and fractions of n-hexane E. fluctuans 57.03, 114.06, and 171.09 mg/kg, respectively (Group 4, 5 and 6). For 21 days, rats were fed the n-hexane fraction orally. On day 1 and day 21 of treatments, blood sugar levels were measured. The histophatology of the liver, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvate transaminase (SGPT) level were estimated.
At a dosage of 57.03 mg/kg was substantially (p < 0.05) beneficial in decreasing blood sugar and SGOT. The n-hexane fraction of E. fluctuans ameliorated liver damage in diabetic rats and avoided diabetes complications, according to our findings. As a result, E. fluctuans has a considerable amount of potential as a novel diabetic therapy.
Keywords: Diabetes, Enhydra fluctuans, Insulin resistance, Liver cells regeneration.
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