Trimester-Specific Free Thyroid Hormones Levels among Pregnant Women in Nineveh Governorate,Iraq
DOI:
https://doi.org/10.31351/vol33iss2pp79-85Keywords:
FT3 and FT4,Trimester-specific,Serum levels,Pregnant women, Nineveh governorateAbstract
Abstract
There are numerous physiological changes in thyroid gland functions occur during conception that lead
to differ in thyroid hormones levels. Therefore, American Thyroid Association (ATA) guidelines
recommended determination of population specific reference serum levels for thyroid hormones in
different trimesters. Aim of current study is to establish trimester –specific reference serum levels
(TSRSLs) for free triiodothyronine (FT3) and free thyroxine (FT4) in apparently healthy pregnant females
in Nineveh governorate, Iraq.
Accordingly, a cross-sectional study was carried out from Dec. 2020 to Apr. 2021 in Al-Batool Teaching
hospital, Al-khanssa Maternity Teaching Hospital, Al-Noor Primary Health Center (PHC) and Out- patient
clinics in Nineveh governorate. A total of 300 pregnant women were enrolled in this study after
obtaining oral and written consent, 140 were excluded since they were met one or more of exclusion
criteria, other 10 found to be positive anti-thyroid peroxide were also excluded from the study. The
remaining 150 pregnant females aged (16-42) years were enrolled in this study, 50 of them were
assigned to each trimester.The following parameters FT4 and FT3 were measured for each participants.
The result of this study showed the TSRSLs of FT4 were (0.70-1.29, 0.49-1.31 and 0.58-1.28 ng/dl) for the
1st, 2nd and 3rd trim, respectively and for FT3 were ( 2.63-3.96, 2.04-3.3 and 2.11-3.40 pg/ml) for the
1st, 2nd and 3rd trim, respectively. The mean FT4 and FT3 was significantly decreased (P=0.002 and
P<0.0001), respectively. from 1st to 3rd trim. The current study are reported the TSRSLs of FT3 and FT4
for the first time in Nineveh governorate. We concluded nearly similar TSRSLs of FT3 and FT4 to that
recorded elsewhere
Received 13/12/2022
Accepted 29/5/2023
Published 27/6/2024
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References
Arrangoiz R, Cordera F, Caba D, Muñoz M, Moreno E, de León EL. Comprehensive review of thyroid embryology, anatomy, histology, and physiology for surgeons. International Journal of Otolaryngology and Head & Neck Surgery.201 8 ; 7:160 -188.
Brent GA. Mechanism of thyroid hormone action.J Clin Invest. 2012 Sep;122(9):3035-43.
Moleti M, Trimarchi F, Vermiglio F. Thyroid physiology in pregnancy. Endocr Pract. 2014;20:589-96.
Muller I, Taylor PN, Lazarus JH. Thyroid function in pregnancy. Ann Thyroid. 2018; 3:27.
.Park C. Evaluation of pregnancy and thyroid function. Korean J Clin Lab Sci. 2018 ;50(1):1-10.
Soldin OP. Thyroid function testing in pregnancy and thyroid disease: trimester-specific reference intervals. Ther Drug Monit. 2006 Feb;28(1):8-11.
Spencer CA. Assay of thyroid hormones and related substances. In: Feingold KR, Anawalt B, Boyce A, et al. Endotext 2017. South Dartmouth (MA): MDText.com, Inc.; 2000.
Bulur O, Atak Z, Ertugrul DT, Beyan E, Gunakan E, Karakaya S, et al.Trimester-specific reference intervals of thyroid function tests in Turkish pregnants. Gynecological Endocrinology 2020 May 3;36(5):413-6
. Zhang D, Cai K, Wang G, Xu S, Mao X, Zheng A,et al. Trimester-specific reference ranges for thyroid hormones in pregnant women. Medicine. 2019 Jan;98(4).
Sheng Y, Huang D, Liu S, Guo X, Chen J, Shao Y, et al. Reference intervals of thyroid hormones and correlation of BMI with thyroid function in healthy Zhuang Ethnic pregnan women. BioMed Research International 2018 Nov 14; 2018.
Rifai N. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8 E; South Asia Edition; e-Book. Elsevier India; 2019 Jul 16
Murillo-Llorente MT, Fajardo-Montañana C, Pérez-Bermejo M. Reference values of thyroid hormones during the first trimester of regnancy in Valencian Community (Spain) and their relationship with iodine intake.Nutrients. 2020;12(5): 1433.
Amouzegar A, Khazan M, Hedayati M,Azizi F. An assessment of the iodine status and the correlation between iodine nutrition and thyroid function during pregnancy in an iodine sufficient area. Eur. J. Clin. Nutr. 2014; 68: 397–400.
14-Medici M, Korevaar TI, Visser WE, Visser TJ,Peeters RP. Thyroid function in pregnancy: what is normal? Clin Chem 2015 May 1;61(5):704-13.
15-Surks MI, Boucai L. Age- and race-based serum thyrotropin reference limits. J Clin Endocrinol Metab. 2010;95(2):496–502.
Iodine Global Network.[Internet]. Annual report. 2019;p11.[cited 3 Oct.2021].Available from http://www.ign.org/index.cfm
17-Portulano C, Paroder-Belenitsky M, Carrasco N.The Na+/I− Symporter (NIS): Mechanism and medical impact. Endocrine Reviews. 2014 ;35:106 -149.
18-.Korevaar TI, Medici M, Visser TJ,P eeters RP. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat Rev Endocrinol 2017;13 (10):610
19-Kostecka-Matyja M, Fedorowicz A, Bar-Andziak E, Bednarczuk T, Buziak-BerezaM, Dumnicka P, et al. Reference values for tsh and free thyroid hormones in healthy pregnant women in Poland: A Prospective, Multicenter Study.Eur Thyroid J. 2017 Apr;6(2):82-88.
SheribaN.A.,IbrahimN,A.,MohamedN,R. and HegabA.M.,Assessment of normal range of thyroid function tests in healthy Egyptian pregnant women. Thyroid Res Pract,15(2),70-74(2018)
Lin H, Ye M, Zhou Z, Yuan L, Lash GE, Zhang G, et al. Reference values and the effect of clinical parameters on thyroid hormone levels during early pregnancy. Biosci Rep. 2021 Jan 29;41(1):BSR20202296.
Kim HJ, Cho YY, Kim SW, Kim TH, Jang HW, Lee SY,et al. Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area. Korean J Intern Med. 2018 May;33(3):552-560
Sun R, Xia J. The reference intervals of thyroid hormones for pregnant women in zhejiang province. Lab Med. 2017 Dec 22;49(1)
Rani K.S., Tirupati S., Sarathi S. Kumar.K.D.,Trimester –specific reference ranges for thyroid function tests in South Indian women.Thyroid Res Pract 2018;15;117.
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