The Role of Collagen I, Magnesium and Phosphorus in Iraqi Meningioma Patients
DOI:
https://doi.org/10.31351/vol33iss1pp123-128Keywords:
Meningiomas . Collagen I . Magnesium . PhosphorusAbstract
Meningiomas are the most common primary intracellular slow growing benign tumor that are mostly arisen from meningeothelial (arachnoid) cells which surround the brain and the spinal cord. The aim of the present study is to innovate a biochemical relationship between collagen I and meningiomas in Iraqi patients and also to examine the biochemical role of magnesium and phosphorus regarding this complex nervous disease. Thirty (30) diagnosed meningioma patients were participated in the present study and were classified into two (2) groups : G3 composed of (15) newly diagnosed meningioma males and G4 composed of (15) newly diagnosed meningioma females , both G3 and G4 subjects did not take any treatment linked with meningioma or any chronic disease. Patients groups were compared with healthy subjects as two control groups which did not suffer from any chronic disease , the first G1 composed of (15) healthy males and the second G2 composed of (15) healthy females in the range of age matched with patients groups. Blood samples were collected from each subject enrolled in this study and three biochemical parameters (collagen I , magnesium , phosphorus ) were determined in sera of all groups. Results of the present study have reported that levels of collagen I , magnesium and phosphorus were highly significant decreased in sera of G3 and G4 compared with G1 and G2 respectively , while the difference between G3 and G4 was non significant for the three biochemical parameters. The present study has contributed to collagen I novelty regarding Iraqi patients with meningiomas deficiency and also highlighted the biochemical role of both magnesium and phosphorus in accordance with meningiomas. The present study recommends checking periodically the levels of collagen I , magnesium and phosphorous by laboratory tests and treatment with collagen supplements tablets and metabolics ( magnesium phosphate ) capsules if a deficeicy has been noticed. .………………
Received: 25/1 / 2023
Accepted: 16/4 /2023
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Ogasawara , C. , Philbrick , B. and Adamson , D. Meningioma : A review of epidemiology , pathology , diagnosis . Biomedicines . 2021; 9(1):319.
Buerki R. , Horbinski C. and Kruser T. et al. An overview of meningiomas. Future Oncol. 2008; 14(2):2161-2177.
3. Sandhu , S. , Gupta , S. and Single , K. Collagen in health and disease. J. orofac. Sci. 2012; 3:153- 159.
Gelse, K. , Poschl E. and Aigner T. Collagens- structure , function and biosynthesis. Adv. Drug Deliv. Rev. 2003; 55:1531-1546.
5. Zhang , J. , Zhang , B. and Lin , W. Magnesium promotes the regeneration of the peripheral nerve. Front. Cell and Dev. Biol. 2021; 9(1):717854.
Serna , J. and Bergwitz , C. Importance of dietary phosphorous for bone metabolism and healthy aging. Nutrients . 2020; 12(1):3001.
Nishikimi , A. , Koyama , Y. and Ishihara , S. Collagen- derived peptides modulate CD4+ T cell differentiation and suppress allergic responses in mice. Immun. Inflamm. Dis. 2018;6(2):245-255.
Vaidya , M. , Sheony , A. and Goel , N. Meningiomas with collagenous rosettes : A report of three cases. Asian J. Neurosurg. 2019; 14(1):568-570.
Harkin , J. and Leonard , G. Abnormal aminathoid collagen fibers in meningioma. Acta Neuropathol. 1988 ; 76(1):538-639.
10. Van der Kraan , P. , Bumat , P. and Van Kuppevelt , T. Interaction of chondrocytes , extracellular matrix and growth factors : relevance for articular cartilage tissue engineering. Osteoarthr. cartil. 2002; 10(1):631-637.
Golding , M. , Otero , M. and Plumb , D. et al. Roles of inflammatory and anabolic cytokines in cartilage metabolism : signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur. Cells Mater. 2011; 21:202-220.
Pereira , R. , Martinelli , D. and Cancedda , R. Human articular chondrocytes regulate immune response by affecting directly T cell proliferation and indirectly inhibiting monocyte differentiation to professional antigen –presenting cells. Front. immunol . 2016 ; 7(1):415.
Neo , K. and Tang , B. Collagen 1 signaling at the central nervous system injury site and astrogliosis. Neural Regen. Res. 2021; 12(10):1600-1601.
Reboul , P. , Pelletier , J. and Tardif , G. The new collagenase , collagenase-3 , is expressed and synthesized by human chondrocytes but not by synoviocytes. J Clin Invest. 1996 ; 97(9):2011-2019.
Borch J. , Haslund – Vinding J. and Vilhardt F., et al. Meningioma-Brain Crosstalk : A scoping review. J. Cancers. 2021; 13(1):4267.
NCT number :NCT03558516 . The effects of magnesium sulphate on intraoperative blood loss in meningioma patient undergoing craniotomy with tumor removal : A prospective randomized study. 2018; Document date : 1 August 2018.
Canelas H. , Jorge F. and Tenuto R. et al. Biochemistry of meningiomas. ARQ. NEURO- PSIQUIAI. 1970 ; 28(1):17-23.
Liao , Y. ,Yu , Q. and Zhang , J. Cellular response of chondrocytes to magnesium alloys for orthopedic application. Int. J. of Mol. Med. 2015; 36(1):73-82.
Bouvier C. , Liprandi A. and Colin C. et al. Lack of alkaline phosphatase activity predicts meningioma recurrence. J. Clin. Pathol. 2005 ; 124 (1) : 252-258.
Sharma , U. , Pal , D. and Prasad , R. Alkaline phosphatase : An overview. Int. j. clin. Chem. Lab. 2014 ; 29(3):269-278.
Riboni , L. , Ghidoni , R. and Sonnino , S. et al. Phospholipid content and composition of human meningiomas. Neruochem. J. 1984; 2(1):171-188.
Raghu , R. , Joseph , A. and Krishnan , H. et al. Phosphoinositides : Regulators of nervous system function in health and disease. Front. Mol. Neurosci. 2019 ; 12(208):1-26.
Heally , L. and Antel , J. Sphingosine -1- phosphate receptors in the central nervous and immune systems. Curr. Drug Target. 2016; 17(1):1-10.
Lauretta , R. , Sanone , M. and Sanone , A. Gender in endocrine diseases : Role of gonadal hormones. Int J Endocrinol. 2018; 4847376. doi:10.1155/2018/4847376.PMID:30420884;PMCID:PMC6215564.
Kim , J. , Lee , M. and Dan , H. Gender differences in factors affecting life satisfaction of the elderly with multimorbidity in Korea. Nurs. Rep. 2021; 11(1):54-63.
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