Pterostilbene Effect on Inflammatory and Oxidation Markers in Benign Prostatic Hyperplasia Rats Model
DOI:
https://doi.org/10.31351/vol33iss2pp14-19Keywords:
Pterostilbene, benign prostatic hyperplasia, , Tumor necrosis factor alpha, Glutathione-peroxidase, Malondialdehyde.Abstract
Pterostilbene is a potent anti-inflammatory and antioxidant used to treat benign prostatic hyperplasia, which is brought on by the induction of testosterone propionate. The objective of the current experiment was to assess the efficacy of pterostilbene treatment in comparison to finasteride and resveratrol by tracking various inflammatory and oxidative markers in a male rat with lower urinary tract symptoms consistent with benign prostatic hyperplasia.
The forty-eight male rats were divided into sex groups: the control group, which included eight rats given oil vehicle subcutaneously for 42 days; the induction group, which included eight rats given testosterone propionate(4mg/kg/day) subcutaneously daily dose for fourteen days; and the finasteride group, which included eight rats given finasteride 0.44 mg/kg orally for twenty-eight days after induction Benign prostatic hyperplasia , and the Pterostilbene group, which consisted of 8 rats, got Pterostilbene 200 mg/kg administered orally for 28 days after 14 day Benign prostatic hyperplasia induction, and the other group, which consisted of 8 rats, received Pterostilbene at a dose of 100 mg/kg Use oral gavage to provide 100 mg/kg for the same time period. While the Resveratrol group, which received 100 mg/kg of resveratrol orally. During the identical time frame after Benign prostatic hyperplasia Induction.
There were significant differences in the tissue levels of inflammatory markers and oxidative markers Tumor necrosis factor alpha and Glutathione-peroxidase & Malondialdehyde when comparing the pterostilbene 200 group to the induction group (P ≤0.05).
Pterostilbene has potent antioxidant and anti-inflammatory properties that help to lessen the growth of the benign prostatic hyperplasia that testosterone propionate causes.
Received 2/2/2023
Accepted 4/5/2023
Published 27/6/2024
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References
Eid BG, Abdel-naim AB. Piceatannol Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Modulation of Nrf2 / HO-1 / NF κ B Axis. 2020;11(December):1–11.
Lokeshwar SD, Harper BT, Webb E, Jordan A, Dykes TA, Neal DE, et al. Epidemiology and treatment modalities for the management of benign prostatic hyperplasia. Transl Androl Urol 2019;8(5):529–39.
Article R. Pathophysiology of benign prostate enlargement and lower urinary tract symptoms: Current concepts. 2017;29(2):79–83.
Wu X, Gu Y, Li L. The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats. Toxicol Lett 2017;265:9–16.
Choi Y jin, Kim E kyung, Fan M, Tang Y, Hwang YJ. E ff ect of Paecilomyces tenuipes Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Sprague – Dawley Rats. :1–10.
Delmas V, Schulman C. European Urology. Eur Urol 2001;40(4).
Mohammed ES, Al-taie WF, Numan IT. Study of Interleukin-6 , Testosterone and Zinc in Different Clinicopathological Stages of Malignant Prostate Cancer Patients. 2012;23(5):79–88.
Xu Z, Zhu L, Chen H, Hou T. Pterostilbene inhibits hepatocellular carcinoma proliferation and HBV replication by targeting ribonucleotide reductase M2 protein. 2021;(August).
Singh A, Singh S. Author ’ s Accepted Manuscript. Eur J Pharmacol 2016;
10. Obrador E, Salvador-palmer R, Jihad-jebbar A, Rafael L, Dellinger TH, Dellinger RW, et al. Pterostilbene in Cancer Therapy. 2021;
Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: Biomedical applications. Crit Rev Clin Lab Sci 2013;50(3):65–78.
Wang P. Review Article Metabolism and pharmacokinetics of resveratrol and pterostilbene. :1–10.
Mizokami A, Koh E, Izumi K, Narimoto K, Takeda M, Honma S, et al. Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone. Endocr Relat Cancer 2009;16(4):1139–55.
Heinlein CA, Chang C. Androgen Receptor (AR) Coregulators: An Overview. Endocr Rev 2002;23(2):175–200.
Cancer LMMM in, 2022 U. Benign Prostatic Hyperplasia: Epidemiology, Pathophysiology, and Clinical Manifestations. books.google.com
Qian X, Gu Z, Guan W, Qi J, Xu D. Resveratrol could attenuate prostatic inflammation in rats with Oestradiol-induced chronic prostatitis. Andrologia 2021;53(4):e14004.
Zhao R, Wang X, Jiang C, Shi F, Zhu Y, Yang B, et al. Finasteride accelerates prostate wound healing after thulium laser resection through DHT and AR signalling. Cell Prolif 2018;51(3):e12415.
Seok H, Kim SK, Yoo KH, Lee BC, Kim YO, Chung JH. Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population. J Exerc Rehabil 2014;10(6):383.
View of Significance of Serum Soluble Fas (sFas/CD95) and Tumor Necrosis Factor- Alpha (TNF-α) in Radiologically Diagnosed Patients with Uterine Leiomyoma.
Liu J, Fan C, Yu L, Yang Y, Jiang S, Ma Z, et al. Cytokine Pterostilbene exerts an anti-inflammatory effect via regulating endoplasmic reticulum stress in endothelial cells. Cytokine 2016;77:88–97.
Udensi UK, Tchounwou PB. Oxidative stress in prostate hyperplasia and carcinogenesis. 2016;35(1):1–19.
Vital P, Castro P, Ittmann M. Oxidative stress promotes benign prostatic hyperplasia. Prostate 2016;76(1):58–67.
Kalu WO, Okafor PN, Ijeh II, Eleazu C. Effect of kolaviron, a biflavanoid complex from Garcinia kola on some biochemical parameters in experimentally induced benign prostatic hyperplasic rats. Biomed Pharmacother 2016;83:1436–43.
Arsova-Sarafinovska Z, Eken A, Matevska N, Erdem O, Sayal A, Savaser A, et al. Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer. Elsevier; 2009.
Aydin A, Arsova-Sarafinovska Z, Sayal A, Eken A, Erdem O, Erten K, et al. Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia. Clin Biochem 2006;39(2):176–9.
Bhakkiyalakshmi E, Sireesh D, Sakthivadivel M, Sivasubramanian S, Gunasekaran P, Ramkumar KM. Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes. Eur J Pharmacol 2016;777:9–16.
CHEN X, YAO Z, PENG X, WU L, WU H, OU Y, et al. Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF-κB signaling pathway. Mol Med Rep 2020;22(6):5135–44.
Shabani E, Kalantari H, Kalantar M, Goudarzi M, Mansouri E, Kalantar H. Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats. BMC Complement Med Ther 2021;21(1):1–10.
Mladenović D, Petronijević N, Stojković T, Velimirović M, Jevtić G, Hrnčić D, et al. Finasteride has regionally different effects on brain oxidative stress and acetylcholinesterase activity in acute thioacetamide-induced hepatic encephalopathy in rats. PLoS One 2015;10(8).
Ray PS, Maulik G, Cordis GA, Bertelli AAE, Bertelli A, Das DK. The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radic Biol Med 1999;27(1–2):160–9.
LiuTingting, QiHe, MaLong, LiuZhaojun, FuHuiling, ZhuWenzhen, et al. Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri. https://home.liebertpub.com/rej 2015;
Gürocak S, Karabulut E, Karadaǧ N, Ozgor D, Ozkeles N, Bay Karabulut A. Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver. Asian Pacific J Cancer Prev 2013;14(4):2367–70.
Dudka J, Gieroba R, Korga A, Burdan F, Matysiak W, Jodlowska-Jedrych B, et al. Different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity. Evidence-based Complement Altern Med 2012;2012.
Kishido T, Unno K, Yoshida H, Choba D, Fukutomi R, Asahina S, et al. Decline in glutathione peroxidase activity is a reason for brain senescence: Consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain. Biogerontology 2007;8(4):423–30.
Zakaria MMH, Hajipour B, Estakhri R, Saleh BM. Anti-oxidative effect of resveratrol on aluminum induced toxicity in rat cerebral tissue. Bratisl Lek Listy 2017;118(5):269–72.
Paulis G. Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy. Res Reports Urol 2018;10:75.
Kumar B, Koul S, Khandrika L, Meacham RB, Koul HK. Oxidative Stress Is Inherent in Prostate Cancer Cells and Is Required for Aggressive Phenotype. Cancer Res 2008;68(6):1777–85.
Zhang C, Lan T, Hou J, Li J, Fang R, Yang Z, et al. NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling. Oncotarget 2014;5(12):4392.
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