Efficacy of Zingiber Officinale (ZO) in The Treatment of Lead Acetate-induced Hepatopathy in Rabbits: An Ultrastructural Assessment of Sub-acute Trial.: Efficacy of Zingiber Officinale (ZO) in the Treatment of Lead Acetate-Induced Hepatopathy in Rabbits

Mohammed Abdulabbas Hasan

doi:10.31351/vol33iss2pp112-120

Authors

Mohammed Abdulabbas Hasan Department of Pathological Analysis, College of Applied Medical Scinces, Al-Shatrah University, Iraq. 2Department of Pathology, Faculty of Medicine, University of Thi-Qar, Iraq. 3Department of Pharmacology and Microbiology, Faculty of Biomedical Science, Universiti Putra Malaysia, Serdang, Malaysia.

DOI:

https://doi.org/10.31351/vol33iss2pp112-120

Keywords:

Lead acetate, Hepatopathy, Ginger, SOD, Ultrastructural changes.

Abstract

Lead acetate (Pb) is a hazardous heavy metal that is well-known to impair the functions of bodily systems and organs. This present study identifies the histopathological alterations that Pb toxicity causes in the liver of rabbits as well as the efficacy of ginger (Zingiber Officinale, ZO) in mitigating its negative effects. As ZO is a rich source of several antioxidants, this present study examines its ability to decrease Pb toxicity in test animals. A total of 30 rabbits were randomly divided into three groups (n = 10). The Control group was only fed distilled water, the Negative group was only fed a 2% Pb solution, while the Treated group was fed a 2% Pb solution as well as 100 mg of ZO extract per kilogram of body weight daily. Lead acetate (Pb) was found to significantly alter the histopathology of rabbit livers by increasing inflammation, fibrosis, vacuolation, and degeneration; significantly decreasing plasma superoxide dismutase (SOD) and catalase (CAT) enzymatic activities; and increasing plasma malondialdehyde (MDA) concentrations. Furthermore, ZO extract not only significantly decreases the negative hepatic impacts of Pb but also prevents Pb-induced hepatopathy.

Received 14/4/2023

Accepted 26/6/2023

Published 27/6/2024

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Efficacy of Zingiber Officinale (ZO) in The Treatment of Lead Acetate-induced Hepatopathy in Rabbits: An Ultrastructural Assessment of Sub-acute Trial.