Resveratrol as an Antiaging Drug: A Review of articles
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https://doi.org/10.31351/vol33iss3pp1-13Keywords:
Keywords: Resveratrol, antiaging mechanisms, aging related diseases.Abstract
Abstract
In recent decades, progressions in care of health have increased the average lifespan, resulting in an increase in old age population. Unfortunately, this has led to an increase in periods of health problems or disabilities, and multiple diseases that associated with aging are responsible for the largest health problems in the majority of developing nations. Many anti-aging approaches such as healthy life styles and medical therapies aimed for reducing the prevalence of bad health conditions and the age associated disease as Alzheimer disease, cardiovascular disease, renal impairment, and cancer. Grapes, peanuts, and blueberries are just a few examples of the many foods that contain resveratrol, numerous reports have shown its importance in antiaging therapy that decreases oxidative stress, lowers inflammation, enhances mitochondrial activity and controls apoptosis. Throughout this review, we will describe the possible antiaging mechanisms of resveratrol and its effect on extension of life span and on many aging-related diseases.
Received 16/5/2023
Accepted 26/7/2023
Published 27/6/2024
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Zhou DD, Luo M, Huang SY, Saimaiti A, Shang A, Gan RY, et al. Effects and mechanisms of resveratrol on aging and age-related diseases. Oxid Med Cell Longev. 2021 Jul 11; 2021:1-5. https:// doi.org/10. 1155/2021/ 9932218
Zhou DD, Luo M, Shang A, Mao QQ, Li BY, Gan RY, et al. Antioxidant food components for the prevention and treatment of cardiovascular diseases: effects, mechanisms, and clinical studies. Oxid Med Cell Longev. 2021 Jan 28; 2021. https://doi.org/10.1155/2021/6627355
Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health benefits and molecular mechanisms of resveratrol: A narrative review. Foods. 2020 Mar 14;9(3):340. https://doi.org/10.3390/foods9030340
Harikumar KB, Aggarwal BB. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell cycle. 2008 Apr 15;7(8):1020-35. DOI: 10.4161/cc.7.8.5740
Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, Neri LM. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. 2018 Mar 3; 9(24):17181. doi: 10.18632/oncotarget.24729
Wang N, Luo Z, Jin M, Sheng W, Wang HT, Long X, et al. Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina. Aging (Albany NY). 2019 May 5; 11(10):3117. DOI: 10.18632/aging.101966
Neves AR, Lucio M, Lima JL, Reis S. Resveratrol in Medicinal Chemistry: A Critical Review of Its Pharmacokinetics. Drug-Delivery and Membrane Interactions. Curr. Med. Chem. 2012; 19:1663-81. doi: 10.2174/ 092986 712799945085.
Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10; 275(5297):218-20. DOI: 10.1126/ science.275.5297.218
Leonard SS, Xia C, Jiang BH, Stinefelt B, Klandorf H, Harris GK, et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. 2003 Oct 3; 309(4):1017-26. https:// doi.org/ 10.1016/j .bbrc.2003.08.105
Alarcon De La Lastra C, Villegas I. Resveratrol as an anti‐inflammatory and anti‐aging agent: Mechanisms and clinical implications. Mol Nutr Food Res. 2005 May; 49(5):405-30. https://doi.org/10.1002/mnfr.200500022
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extends Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11; 425(6954):191-6. DOI: 10.1038/nature01960
Parker JA, Arango M, Abderrahmane S, Lambert E, Tourette C, et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet. 2005 Apr 1; 37(4):349-50. https://doi.org/10.1038/ng1534.
Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev. 2004 Sep; 22(3):169-88. DOI: 10.1111/j.1527-3466.2004.tb00139.x
Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000 Aug 18; 47(3):549-55. DOI: 10.1016/s0008-6363(00)00102-4
Das DK, Maulik N. Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv. 2006 Feb 1;6(1):36. doi: 10.1124/mi.6.1.7
Xia N, Daiber A, Förstermann U, Li H. Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol. 2017 Jun; 174(12):1633-46. https://doi.org/10.1111/bph.13492
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science. 2013 Mar 8; 339(6124):1216-9. DOI: 10.1126/science.1231097
Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, et al. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab. 2012 Dec 5; 16(6):738-50. DOI: 10.1016/j.cmet.2012.11.007
Kopff M, Zakrzewska I, Czernicki J, Klem J, Strzelczyk M. Red cell superoxide dismutase and catalase activity in multiple sclerosis. Acta Biochimica Polonica. 1993 Mar 31; 40(1):154-7. PMID: 8372545
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007 Jan 1; 39(1):44-84. https://doi.org/10.1016/j.biocel.2006.07.001
Cosín-Tomàs M, Senserrich J, Arumí-Planas M, Alquézar C, Pallàs M, Martín-Requero Á, et al. Role of resveratrol and selenium on oxidative stress and expression of antioxidant and anti-aging genes in immortalized lymphocytes from Alzheimer’s disease patients. Nutrients. 2019 Jul 31; 11(8):1764. https://doi.org/10.3390/nu11081764
Inglés M, Gambini J, Miguel MG, Bonet-Costa V, Abdelaziz KM, El Alami M et al. PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations. Biomed Res Int. 2014; 2014:580852. DOI: 10.1155/2014/580852
Fu S, Lv R, Wang L, Hou H, Liu H, Shao S. Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway. Saudi J Biol Sci. 2018; 25(2):259-266. doi: 10.1016/j.sjbs.2016.10.019
Yun H, Park S, Kim MJ, Yang WK, Im DU, Yang KR, et al. AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1. FEBS J. 2014; 281(19):4421-4438. DOI: 10.1111/febs.12949
Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, et al. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H18-24. doi: 10.1152/ajpheart.00260.2010
Li S, Zhao G, Chen L, Ding Y, Lian J, Hong G, et al. Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. Mol Med Rep. 2016 Feb 1; 13(2):1833-8. https://doi.org/10.3892/mmr.2015.4710.
Zhou X, Yang J, Zhou M, Zhang Y, Liu Y, Hou P, et al. Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB. Nutr Metab. 2019 Dec; 16:1-2. https://doi.org/10.1186/s12986-019-0371-6
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol.2011 Feb;13(2):132-41. DOI: 10.1038/ncb2152
López-Lluch G, Hernández-Camacho JD, Fernández-Ayala DJ, Navas P. Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?. Biogerontology. 2018 Dec; 19:461-80. https://doi.org/10.1007/s10522-018-9768-2
Zhang J, Chiu J, Zhang H, Qi T, Tang Q, Ma K, et al. Autophagic cell death induced by resveratrol depends on the Ca(2+)/AMPK/mTOR pathway in A549 cells. Biochem Pharmacol. 2013; 86(2):317-328. doi:10.1016/j.bcp.2013.05.003
Pagano G, Pallardó FV, Lyakhovich A, Tiano L, Fittipaldi MR, Toscanesi M, et al. Aging-related disorders and mitochondrial dysfunction: a critical review for prospect mitoprotective strategies based on mitochondrial nutrient mixtures. Int J Mol Sci. 2020 Sep 25; 21(19):7060. https://doi.org/10.3390/ijms21197060
Natarajan V, Chawla R, Mah T, Vivekanandan R, Tan SY, Sato PY, et al. Mitochondrial dysfunction in age‐related metabolic disorders. Proteomics. 2020 Mar; 20(5-6):1800404. DOI: 10.1002/pmic.201800404
Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H13-20. https://doi.org/10. 1152/ ajpheart.00368 .2009
Beauloye C, Bertrand L, Horman S, Hue L. AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc Res. 2011 May 1; 90(2):224-33. DOI: 10.1093/cvr/cvr034
Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto JT, Bagi Z, Ballabh P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009; 297(5):H1876-H1881. DOI: 10.1 152/ ajpheart .00375.2009
Sugiyama M, Kawahara-Miki R, Kawana H, Shirasuna K, Kuwayama T, Iwata H. Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows. J Reprod Dev. 2015; 61(4):251-9. https:/ /doi.org/10. 1262/jrd.2015-001
Wang N, Luo Z, Jin M, Sheng W, Wang HT, Long X, et al. Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina. Aging. 2019 May 5; 11(10):3117.doi: 10. 18632 /aging .101966
Liang QX, Lin YH, Zhang CH, Sun HM, Zhou L, Schatten H, et al. Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo. Aging. 2018 Jul;10(7):1586. doi: 10.18632/aging.101494
Argüelles S, Guerrero‐Castilla A, Cano M, Muñoz MF, Ayala A. Advantages and disadvantages of apoptosis in the aging process. Ann N Y Acad Sci. 2019 May;1443(1):20-33. https://doi.org/10.1111/nyas.14020
Higami Y, Shimokawa I. Apoptosis in the aging process. Cell Tissue Res. 2000 Jul; 301:125-32. DOI: 10.1007/s004419900156
Xiong WX, Chai ZT, Wang B, Zhou GX, Cang J, Xue ZG, et al. Resveratrol alleviates learning and memory impairment in aged rats after general anesthesia with sevoflurane and nitrous oxide via SIRT1-p53 signaling pathway. Bosn J Basic Med Sci. 2022; 22(1):110-117. Published 2022 Feb 1. doi: 10.17305/bjbms.2021.5997
Maureen Redza-Dutordoir , Diana A. Averill-Bates Activation of apoptosis signalling pathways by reactive oxygen species Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1863, Issue 12, December 2016, Pages 2977-2992 https://doi.org/10.1016/j.bbamcr.2016.09.012
Eleawa SM, Alkhateeb MA, Alhashem FH, et al. Resveratrol reverses cadmium chloride-induced testicular damage and subfertility by downregulating p53 and Bax and upregulating gonadotropins and Bcl-2 gene expression. J Reprod Dev. 2014; 60(2):115-127. doi: 10.1262/jrd.2013-097
Malhotra A, Bath S, Elbarbry F. An organ system approach to explore the antioxidative, anti-inflammatory, and cytoprotective actions of resveratrol. Oxid Med Cell Longev. 2015 Jun 9; 2015.https://doi.org/10.1155/2015/803971
Bournival J, Quessy P, Martinoli MG. Protective effects of resveratrol and quercetin against MPP+-induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cell Mol Neurobiol. 2009 Dec; 29:1169-80. https://doi.org/10.1007/s10571-009-9411-5
Li J, Li L, Wang S, Zhang C, Zheng L, Jia Y, et al. Resveratrol alleviates inflammatory responses and oxidative stress in rat kidney ischemia-reperfusion injury and H2O2-induced NRK-52E cells via the Nrf2/TLR4/NF-κB pathway. Cell Physiol Biochem. 2018; 45(4):1677-89.https://doi.org/10.1159/0004 87735
Fougère B, Boulanger E, Nourhashémi F, Guyonnet S, Cesari M. Retracted: chronic inflammation: accelerator of biological aging. J Gerontol A Biol Sci Med Sci. 2017 Sep 1; 72(9):1218-25. DOI: 10.1093/gerona/glw240
Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018 Sep; 15(9):505-22. https://doi.org/10.1038/s41569-018-0064-2
Bellaver B, Souza DG, Souza DO, Quincozes-Santos A. Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats. Toxicol In Vitro. 2014 Jun 1; 28(4):479-84. https://doi.org/10.1016/j.tiv.2014.01.006
Csiszar A, Sosnowska D, Wang M, Lakatta EG, Sonntag WE, Ungvari Z. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. J Gerontol A Biol Sci Med Sci. 2012 Aug 1; 67(8):811-20. https://doi.org/10.1093/gerona/glr228
Ginés C, Cuesta S, Kireev R, García C, Rancan L, Paredes SD, et al. Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice. Exp Gerontol. 2017 Apr 1; 90:61-70. DOI: 10.1016/j.exger.2017.01.021
Ren J, Zhang Y. Targeting autophagy in aging and aging-related cardiovascular diseases. Trends Pharmacol Sci. 2018 Dec 1; 39(12):1064-76. https:// doi.org/ 10.1016/j. tips.2018.10.005
Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 2010 Jan; 1(1):e10-e10.https://doi.org/10.1038/cddis.2009.8.
Costa C, Lodesani M, Maistrello L. Effect of thymol and resveratrol administered with candy or syrup on the development of Nosema ceranae and on the longevity of honeybees (Apis mellifera L.) in laboratory conditions. Apidologie. 2010 Mar 1; 41(2):141-50. https://doi.org/10.1051/apido/2009070
Chandrashekara KT, Shakarad MN. Aloe vera or resveratrol supplementation in larval diet delays adult aging in the fruit fly, Drosophila melanogaster. J Gerontol A Biol Sci Med Sci. 2011 Sep 1; 66(9):965-71. https://doi.org/10.1093/gerona/glr103
Yu X, Li G. Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri. Exp Gerontol. 2012 Dec 1; 47(12):940-9. https:// doi.org/ 10.1016/ j.exger. 2012.08.009.
Kodali M, Parihar VK, Hattiangady B, Mishra V, Shuai B, Shetty AK. Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation. Sci Rep. 2015 Jan 28; 5:8075. DOI: 10.1038/srep08075
Sarubbo F, Ramis MR, Aparicio S, Ruiz L, Esteban S, Miralles A, et al. Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats. Age (Dordr). 2015 Jun; 37(3):9777. DOI: 10.1007/s11357-015-9777-x
Gocmez SS, Gacar N, Utkan T, Gacar G, Scarpace PJ, Tumer N. Protective effects of resveratrol on aging-induced cognitive impairment in rats. Neurobiol Learn Mem. 2016 May; 131:131-6. DOI: 10.1016/j.nlm.2016.03.022
Serino A, Salazar G. Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease. Nutrients. 2018 Dec 28; 11(1):53. DOI: 10.3390/nu11010053
Fajemiroye JO, da Cunha LC, Saavedra-Rodríguez R, Rodrigues KL, Naves LM, Mourão AA, et al. Aging-Induced Biological Changes and Cardiovascular Diseases. Biomed Res Int. 2018 Jun 10; 2018:7156435. DOI: 10.1155/2018/7156435
Rajapakse AG, Yepuri G, Carvas JM, Stein S, Matter CM, Scerri I, et al. Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol. PLoS One. 2011 Apr 22; 6(4):e19237. DOI: 10.1371/journal.pone.0019237
Hui Y, Lu M, Han Y, Zhou H, Liu W, Li L, et al. Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats. Acta Histochem. 2017 May; 119(4):392-399. DOI: 10.1016/j.acthis.2017.04.002
Chen CC, Chang ZY, Tsai FJ, Chen SY. Resveratrol Pretreatment Ameliorates Concanavalin A-Induced Advanced Renal Glomerulosclerosis in Aged Mice through Upregulation of Sirtuin 1-Mediated Klotho Expression. Int J Mol Sci. 2020 Sep 15; 21(18):6766. DOI: 10.3390/ijms21186766
Kim DH, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, et al. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F427-35. DOI: 10.1152/ajprenal.00258.2010
Al-Hussaini H, Kilarkaje N. Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys. Toxicol Appl Pharmacol. 2018 Jan 15; 339:97-109. DOI: 10 .1016 /j.taap .2017 .11.025
Soufi FG, Vardyani M, Sheervalilou R, Mohammadi M, Somi MH. Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats. Gen Physiol Biophys. 2012 Dec; 31(4):431-8. DOI: 10.4149/gpb_2012_039
Zhang W, Liu Y, Ge M, Jing J, Chen Y, Jiang H, et al. Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats. Nutr Res Pract. 2014 Apr; 8(2):220-6. DOI: 10.4162/nrp.2014.8.2.220
Bai Y, Lu H, Wu C, Liang Y, Wang S, Lin C, et al. Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway. Biochem Pharmacol. 2014 Dec 1; 92(3):484-93. DOI: 10.1016/j.bcp.2014.09.002
Özatik FY, Özatik O, Yiğitaslan S, Ünel ÇÇ, Erol K. Protective role of resveratrol on testicular germ cells in mice with testicular toxicity. Turk J Urol. 2017; 43(4):444-450. doi: 10.5152/tud.2017.34101
Banerjee B, Chakraborty S, Chakraborty P, Ghosh D, Jana K. Protective Effect of Resveratrol on Benzo(a)Pyrene Induced Dysfunctions of Steroidogenesis and Steroidogenic Acute Regulatory Gene Expression in Leydig Cells. Front Endocrinol (Lausanne). 2019;10:272. Published 2019 Apr 30. doi: 10.3389/fendo.2019.00272.
Li E, Guo Y, Wang G, Chen F, Li Q. Effect of resveratrol on restoring spermatogenesis in experimental cryptorchid mice and analysis of related differentially expressed proteins. Cell Biol Int. 2015 Jun; 39(6):733-40. DOI: 10.1002/cbin.10441
El Bana E, Sarg N, Elwakeel E. The Histological and Immunohistochemical Study of Tramadol Induced Testicular Toxicity and Protective Effects of Resveratrol in Adult Male Albino Rats. Journal Medical Histology. 2019 Dec 1; 3(2):207-15.DOI: 10.21608 /jmh.2019 .15928.1064.
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