Impact Of Clinical Pharmacist-Led Interventions on Short Term Quality Of Life Among Multiple Sclerosis Patients Taking Disease-Modifying Therapy
DOI:
https://doi.org/10.31351/vol34iss1pp256-265Keywords:
clinical pharmacist intervention, quality of life, multiple sclerosisAbstract
Multiple Sclerosis has a substantial impact on a patient's quality of life. Pharmacists have a significant effect on the treatment of people with multiple sclerosis (MS) and may contribute to enhancing their quality of life (QoL). This study aims to evaluate the efficacy of pharmacist-led intervention (PI) on the quality of life of Patients with multiple sclerosis taking disease-modifying therapy (DMTs). This was a Pre-Post intervention study on patients with relapsing-remitting multiple sclerosis and receiving DMTs who attended a neurological consultant clinic in the medical city of Baghdad. Each patient received two educational sessions: The first at baseline after filling the face validation Arabic version of multiple sclerosis quality of life (MSQOL-29item) at baseline and the second after a month. each session lasted approximately 30-45 minutes, and the patients received educational counselling. A formal Arabic pamphlet was prepared for each patient. Then, After two months, The researcher asked the patients to refill the same questionnaire. eighty patients with RRMS were enrolled in the study, and sixty-five of these patients ultimately completed the study. The mean age of participants is 30.64+_8.54. The clinical pharmacist's intervention significantly improved the physical health composite (PHC) and mental health composite(MHC). only physical function in the PHC and changes in health were non-significantly affected by pharmacist intervention. The changes in scores before and after intervention were non-significantly differences in all demographic data groups. Finally, the study concluded that the clinical pharmacist-led educational intervention may enhance the quality of life of multiple sclerosis patients and play a crucial role in reducing DMTs complications.
How to Cite
Publication Dates
Received
Revised
Accepted
Published Online First
References
Hamid MMA El, Ali NM, Saad MN, Mabrouk MS, Shaker OG. Multiple sclerosis: an associated single-nucleotide polymorphism study on Egyptian population. Network Modeling Analysis in Health Informatics and Bioinformatics. 2020;9(1):48.
Yahya RN, Kasim AA, Al Gawwam GA. Comparing the Quality of Life among Patients with Relapsing Remitting Multiple Sclerosis in Iraq Using Different Disease Modifying Therapies. Iraqi Journal of Pharmaceutical Sciences. 2018;27(2):102–14.
Hassoun HK, Almahdawi A, Al-Bajalan SJ, Sheaheed NM, Kamil MAS, Saeed Ridha SM, et al. Expert opinion on the pharmacological management of multiple sclerosis in women of childbearing age in Iraq. Heliyon. 2023;9(2):e13350.
Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: The impact of fatigue and depression. Journal of the Neurological Sciences. 2002;205(1):51–8.
Göksel Karatepe A, Kaya T, Günaydn R, Demirhan A, Çe P, Gedizlioglu M. Quality of life in patients with multiple sclerosis: the impact of depression, fatigue, and disability. International Journal of Rehabilitation Research. 2011;34(4).
Meyers AR, Gage H, Hendricks A. Health-Related Quality of Life in Neurology. Archives of Neurology. 2000 Aug 1;57(8):1224–7.
Megari K. Quality of Life in Chronic Disease Patients. Health psychology research. 2013 Sep;1(3):e27.
Naseri A, Nasiri E, Talebi M, Karimi K, Talebi M. Does the type of disease-modifying drugs impact on the quality of life in patients with relapsing-remitting multiple sclerosis? Romanian Journal of Neurology/ Revista Romana de Neurologie. 2020;19(3):171–8.
Chavan AA, Kumbhar SB, Shinde VR, Thorat AA, Jadhav PB, Jadhav AR, Honrao JB, Shaikh SA, Raysing SD, More VV, Kumbhar DD. Role of pharmacist in healthcare system. GSC Biological and Pharmaceutical Sciences. 2023;24(1):036–45.
Amaslidou A, Ierodiakonou-Benou I, Bakirtzis C, Nikolaidis I, Tatsi T, Grigoriadis N, Nimatoudis I. The role of clinical, demographic and psychological characteristics of people with multiple sclerosis in their physical health related quality of life. Psychiatrike= Psychiatriki. 2023 Feb 10.
Ramanath K V, Santhosh YL. Determining the Impact of Clinical Pharmacist-Provided Patient Education on Quality of Life (QOL) Outcome in Type II Diabetes Mellitus in Rural Population . Challenges and Advances in Pharmaceutical Research Vol 7. 2022 Oct 1;(SE-Chapters):129–41.
Brola W, Kasprzyk M, Fudala M, Opara J. Palliative care for patients with multiple sclerosis. Medycyna Paliatywna/Palliative Medicine. 2013;5(2):41–7.
Castano MAB, Cantero MD, Sánchez ER. 4CPS-208 Telepharmacy interventions in patients with chronic diseases. European Journal of Hospital Pharmacy. 2023 Mar 1;30(Suppl 1):A93 LP-A93.
Homayuni A, Hosseini Z. An intervention design for promoting quality of life among patients with multiple sclerosis: a protocol with a planning approach for a mixed methods study. BMC Neurology. 2023;23(1):42.
Bejjani A, Hwang S, Iyer S. Impact of a Clinical Pharmacist in a Neurology Clinic Treating Patients with Myasthenia Gravis and Multiple Sclerosis. 2021 Oct.
Banks AM, Peter ME, Holder GM, Jolly JA, Markley BM, Zuckerman SL, Choi L, Nwosu S, Zuckerman AD. Adherence to disease-modifying therapies at a multiple sclerosis clinic: the role of the specialty pharmacist. Journal of Pharmacy Practice. 2020 Oct;33(5):605-11.
May A, Morgan O, Quairoli K. Incorporation and Impact of a Clinical Pharmacist in a Hospital-Based Neurology Clinic Treating Patients with Multiple Sclerosis. International Journal of MS Care. 2021;23(1):16–20.
Zuckerman AD, Banks AM, Wawrzyniak J, Rightmier E, Simonson D, Zagel AL, Turco E, Blevins A, DeClercq J, Choi L. Patient-reported outcomes and pharmacist actions in patients with multiple sclerosis managed by health-system specialty pharmacies. American Journal of Health-System Pharmacy. 2023 Nov 15;80(22):1650-61.
Rezapour A, Almasian Kia A, Goodarzi S, Hasoumi M, Nouraei Motlagh S, Vahedi S. The impact of disease characteristics on multiple sclerosis patients’ quality of life. Epidemiology and health. 2017;39:e2017008.
Abdallah ZM, Mohammed AA, Rabee SM, Abd elwahab AA. Assessment Of Health Related Quality Of Life Among Patients With Multiple Sclerosis At Minia University Hospital. Minia Scientific Nursing Journal. 2022;011(1):48–55.
Ismail G, Issa M, El-Hajj T, Tfaily H, Dassouki M, Assaf E, Abboud H, Salameh P, Al-Hajje A, Boumediene F, Yamout B. Quality of life, Knowledge and Access to Treatment in Times of Economic crisis in Lebanon. Multiple Sclerosis and Related Disorders. 2023 Mar 1;71:104328.
Natarajan J, Joseph MA, Al Asmi A, Matua GA, Al Khabouri J, Thanka AN, Al Balushi LD, Al Junaibi SM, Al Ismaili IS. Health-related quality of life of people with multiple sclerosis in Oman. Oman medical journal. 2021 Nov;36(6):e318.
Abbood SK, Assad HC, Al-Jumaili AA. Pharmacist intervention to enhance postoperative fluid prescribing practice in an Iraqi hospital through implementation of NICE guideline. Pharmacy Practice. 2019;17(3):1–8.
Mahdi MZ, Anwer ZM. Evaluating the Impact of Pharmacist Counselling for Asthmatic Children at Karbala Teaching Hospital for Children: An Interventional Prospective Study (Conference Paper). Iraqi Journal of Pharmaceutical Sciences. 2021;30(2):22–30.
Abbas JK, Al-Metwali BZ. The impact of pharmacist behavioral intervention on antibiotics prescribing in pediatric wards. F1000Research 2023 12:458. 2023 May 2 [cited 2024 Mar 8];12:458.
Khazal AA, Jamal MY. The Role of Clinical Pharmacist in Reducing Drug Related Problems in Decompensated Liver Cirrhosis Patients. Iraqi Journal of Pharmaceutical Sciences. 2023;32(2):1–8.
H. Alkashaf K, I. Mohammed S. Impact of Clinical Pharmacist Intervention on Chemotherapy Knowledge, Attitude, and Practice among Breast Cancer Women. Journal of the Faculty of Medicine Baghdad. 2024 Apr 1;66(1 SE-Articles):103–9.
Mikhael EM, Hassali MA, Hussain SA, Nouri AI, Shawky N. Pharmacist-led interventional programs for diabetic patients in Arab countries: A systematic review study. International Journal of Diabetes in Developing Countries. 2019;39(4):600–10.
Al-Jumaili AA, Al-Rekabi MD, Doucette W, Hussein AH, Abbas HK, Hussein FH. Factors influencing the degree of physician–pharmacist collaboration within Iraqi public healthcare settings. International Journal of Pharmacy Practice. 2017 Dec;25(6):411-7.
Rosato R, Testa S, Bertolotto A, Confalonieri P, Patti F, Lugaresi A, Grasso MG, Toscano A, Giordano A, Solari A. Development of a short version of MSQOL-54 using factor analysis and item response theory. PLoS One. 2016 Apr 14;11(4):e0153466.
Kalb R, Brown TR, Coote S, Costello K, Dalgas U, Garmon E, Giesser B, Halper J, Karpatkin H, Keller J, Ng AV. Exercise and lifestyle physical activity recommendations for people with multiple sclerosis throughout the disease course. Multiple Sclerosis Journal. 2020 Oct;26(12):1459-69.
Jeng B, Šilić P, Bollaert RE, Sandroff BM, Motl RW. Physical function across the lifespan in adults with multiple sclerosis: an application of the short physical performance battery. Multiple Sclerosis and Related Disorders. 2023 May 1;73:104624.
Sortino M, Petrigna L, Trovato B, Amato A, Castorina A, D’Agata V, Maugeri G, Musumeci G. An overview of physical exercise program protocols and effects on the physical function in multiple sclerosis: an umbrella review. Journal of Functional Morphology and Kinesiology. 2023 Nov 4;8(4):154.
Chruzander C, Ytterberg C, Gottberg K, Einarsson U, Widén Holmqvist L, Johansson S. A 10-year follow-up of a population-based study of people with multiple sclerosis in Stockholm, Sweden: Changes in health-related quality of life and the value of different factors in predicting health-related quality of life. Journal of the Neurological Sciences. 2014;339(1):57–63.
Hopman WM, Coo H, Pavlov A, Day AG, Edgar CM, McBride E V, et al. Multiple Sclerosis: Change in Health-Related Quality of Life Over Two Years. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2014/12/02. 2009;36(5):554–61.
Janzen W, Turpin KVL, Warren SA, Marrie RA, Warren KG. Change in the Health-Related Quality of Life of Multiple Sclerosis Patients over 5 Years. International Journal of MS Care. 2013 Apr 1;15(1):46–53.
Gustavsen S, Olsson A, Søndergaard HB, Andresen SR, Sørensen PS, Sellebjerg F, et al. The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey. BMC Neurology. 2021;21(1):317.
Kister I, Bacon TE, Chamot E, Salter AR, Cutter GR, Kalina JT, et al. Natural History of Multiple Sclerosis Symptoms. International Journal of MS Care. 2013 Oct 1;15(3):146–56.
Stanton BR, Barnes F, Silber E. Sleep and fatigue in multiple sclerosis. Multiple Sclerosis Journal. 2006 Aug 1;12(4):481–6.
Schmidt S, Jöstingmeyer P. Depression, fatigue and disability are independently associated with quality of life in patients with multiple Sclerosis: Results of a cross-sectional study. Multiple Sclerosis and Related Disorders. 2019;35:262–9.
Zhang Y, Taylor B V, Simpson S, Blizzard L, Campbell JA, Palmer AJ, et al. Feelings of depression, pain and walking difficulties have the largest impact on the quality of life of people with multiple sclerosis, irrespective of clinical phenotype. Multiple Sclerosis Journal. 2020 Sep 14;27(8):1262–75.
Kahraman T, Özdoğar AT, Ertekin Ö, Özakbaş S. Frequency, type, distribution of pain and related factors in persons with multiple sclerosis,. Multiple Sclerosis and Related Disorders. 2019;28:221–5.
Flachenecker P, Henze T, Zettl UK. Spasticity in patients with multiple sclerosis – clinical characteristics, treatment and quality of life. Acta Neurologica Scandinavica. 2014 Mar 1;129(3):154–62.
Hadjimichael O, Vollmer T, Oleen-Burkey M. Fatigue characteristics in multiple sclerosis: the North American Research Committee on Multiple Sclerosis (NARCOMS) survey. Health and quality of life outcomes. 2008 Dec;6:1-1.
Mohammed S, Alhilali D, Mubder N. Perception, benefits, and factors affecting the quality of hospital training course for pharmacy students: A qualitative study with recently graduated pharmacy students. Open Access Macedonian Journal of Medical Sciences. 2022 Oct 23;10(E):1801-6.
Mohammed SI, Dawood EB, Abaas IS. Perceptions and attitudes of community pharmacists towards patient counseling and continuing pharmacy education programs in Iraq. Iraqi Journal of Pharmaceutical Sciences. 2019 Dec 22;28(2):30-6.
Hussain AH, Hussain HA, Mohammed SI. The PharmD Students ’ Beliefs , Perceptions , and Challenges Regarding their First Year in the PharmD Program : A Qualitative Study. Al-Rafidain Journal of Medical Sciences. 2023;102–8.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Iraqi Journal of Pharmaceutical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
