Solubility and Dissolution Enhancement of Lornoxicam by Surface Solid Dispersion
DOI:
https://doi.org/10.31351/vol34iss2pp239-249Keywords:
Hydrophilic insoluble carriers, Dissolution rate, kneading method, Lornoxicam, Surface Solid Dispersion.Abstract
Lornoxicam (LOX) is (NSAID); it is a crystalline powder that ranges in color from orange to yellow and is practically insoluble in water. The aim of this study is to increase the solubility and dissolution of LOX using the surface solid dispersions SSD approach by employing hydrophilic-water insoluble carriers, such as Aerosil 200, Croscarmellose Sodium (CCS), Sodium Starch Glycolate (SSG), Crospovidone and Avicel® PH101. To determine the best drug-carrier interaction, the SSD formulations of LOX were preparing by kneading in various drug: carrier weight ratios (1:1, 1:3, 1:5). They were then assessed for their yield, content of drug, solubility in water, in-vitro release in 7.4 phosphate buffer saline, powder X-ray diffraction, and Fourier Transform Infrared Spectroscopy (FTIR). Most of the prepared SSD formulae demonstrated increased drug solubility. Crospovidone had the most significant results, with a high percentage of yield (98%), high drug content (95.2%), and a 147.6-fold increase in solubility over pure drug solubility with an enhanced dissolution rate. Lornoxicam was transformed into an amorphous form absence of any chemical interaction with the carrier. Therefore, SSD technology successfully increased the solubility and the dissolution rate of LOX.
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References
Mundad MS, Wankhede SS, Patwardhan SK, Avachat AM. Formulation and evaluation of topical gel of lornoxicam using a range of penetration enhancers. Indian J Pharm Educ Res. 2013;47(2):168-71.
Amin Mj, Patel Ks, Patel Dr, Patel Zilp, Bajag J V. Original Article Formulation and Evaluation of Sustained-Release Pellets of Lornoxicam. 2021;13(4). Https:/ /Doi. Org /10. /Ijap . .41601
Verma NK, Singh AK, Mall PC, Yadav V. Identification and characterization of lornoxicam (non-steroidal anti-inflammatory drug). IntJPharmClicRes.2019;1(2):01-3. https ://doi. org/ 10. 33545/ 26647591 .2019 .v1.i2a.7
Mohammadi H, Kumar H V., Roshan S, Bhikshapathi DVRN. Development and Evaluation of Fast Disintegrating Tablets of Lornoxicam Solid Dispersions. Int J Pharm Sci Nanotechnology. 2019;12(4):4585-92. https://doi.org/10.37285/ijpsn.2019.12.4.4
Polat HK, Ünal S, Aytekin E, Karakuyu NF, Haydar MK, Kurt N, et al. Formulation development of Lornoxicam loaded heat triggered ocular in-situ gel using factorial design. Drug Dev Ind Pharm. 2023;49(9):601-15. https:// doi. org/ 10. 1080 /03639045 .2023. 2264932
Yin J, Huang Z, Wu B, Shi Y, Cao C, Lu Y. Lornoxicam protects mouse cornea from UVB-induced damage via inhibition of NF-κB activation. Br J Ophthalmic. 2008;92(4):562-8. https://doi.org/10.1136/bjo.2007.129064
Tawfeek HM, Abdellatif AAH, Abdel-Aleem JA, Hassan YA, Fathalla D. Transfersomal gel nanocarriers for enhancement the permeation of lornoxicam. JDrug DelivSciTechnol2020; 56(January). https:// doi. org /10. 1016 /j.jddst.2020.101540
Gopal Pokhrel, Bikash Dani, Srijana Shrestha, Rakshya Chaudhary, Ramesh Dhami, Barnabas Sunuwar, et al. Formulation, in-vitro Evaluation and Dissolution Enhancement of Griseofulvin by Solid Dispersion Method. J Pharm Pharmacol. 2022;10(4):124-30. https:// doi. org/ 10.17265/2328-2150/2022.04.003
Pelalak R, Rahzani B, Khoshmaram A, Hosseini S, Jamshidian S. Predictive thermodynamic modeling and experimental measurements on solubility of active pharmaceutical ingredient: Lornoxicam case study. 2021;326.
Zewail MB, F. Asaad G, Swellam SM, Abd-allah SM, K. Hosny S, Sallah SK, et al. Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation. Int J Pharm. 2022;624(March). https://doi.org/10.1016/j.ijpharm.2022.122006
Jassim ZE, Mohammed MF, Sadeq ZA. Formulation and evaluation of fast dissolving film of lornoxicam. Asian J Pharm Clin Res. 2018;11(9):217-23.
Sun J, Jin E, Park J won, Choi J seok. Materials Science & Engineering B Piroxicam ternary solid dispersion system for improvement of dissolution (%) and in vitro anti-inflammation effects. Mater Sci Eng B. 2020; 261 (July) :114651. https://doi. org/10. 1016/ j.mseb .2020 .114651
Abd-El Bary A, Louis D, Sayed S. Olmesartan medoxomil surface solid dispersion-based Oro dispersible tablets: Formulation and in vitro characterization. J Drug Deliv Sci Technol. 2014;24(6):665-72. https://doi. org/10 .1016 /S1773 -2247(14)50134-7
Karthikeyan D, Kumar NK, G. Ganesh Kumar, Aswin K. International Journal of Innovative Pharmaceutical Sciences and research enhancement of dissolution of tolbutamide by surface solid dispersion technique. 2014; 2 (2153):2153-68.
Kiran T, Shastri N, Ramakrishna S, MSadanandam. Surface solid dispersion of glimepiride for enhancement of dissolution rate. Int J PharmTech Res. 2009;1(3):822-31.
Daihom BA, Elbortokaly HM, Mohamed MI, Al-mahallawi AM. Dissolution enhancement of olmesartan medoxomil through polymer- based surface solid dispersion and solidified surfactant techniques. 2022;1481-93.
Chaturvedi M, Kumar M, Pathak K, Bhatt S, Saini V. Surface Solid Dispersion and Solid Dispersion of Meloxicam: Comparison and Product Development. 2017;7. https:// doi. org/ 10.15171/apb.2017.068
Alam A. Formulation of solid dispersion and surface solid dispersion of nifedipine: A comparative study. African J Pharm Pharmacol. 2013;7(25):1707-18. https:// doi.org /10.5897/ AJPP12.1180
Hosmani AH, Patil ND, Pawar AA, Honmane SM. Development and Evaluation of Fenofibrate Surface Solid Dispersion for Improved Solubility and Dissolution Rate. 2024;58(2):446-52. https:// doi. org/ 10.5530/ ijper.58.2.50
Essa EA. Enhancement of Carvedilol Dissolution; Surface Solid Dispersion Versus Solid Dispersion. 2015;9(4):283-9.
Khatry S, Sood N, Arora S. Surface Solid Dispersion - A Review. Int J Pharm Sci Nanotechnology. 2013;6(1):1915-25. https:// doi.org/10.37285/ijpsn.2013.6.1.1
Cassano R, Di Gioia ML, Trombino S. Gel-based materials for ophthalmic drug delivery. Gels. 2021;7(3). https://doi.org/10.3390/gels7030130
Polat HK, Ünal S, Aytekin E, Karakuyu NF, Pezik E, Haydar MK, et al. Formulation development of Lornoxicam loaded heat triggered ocular in-situ gel using factorial design. Drug Dev Ind Pharm. 2023;49(9):601-15. https:// doi. org/ 10. 1080 /03639045 .2023. 2264932
Jassim BM, Al-Khedairy EBH. Formulation and in vitro /in vivo Evaluation of Silymarin Solid Dispersion-Based Topical Gel for Wound Healing. Iraqi J Pharm Sci. 2023; 32:42-53. https://doi.org/10.31351/vol32issSuppl.pp42-53
Aziz HA, J. Al-Akkam E. Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets. J Fac Med Baghdad. 2024;65(4). https:// doi. org /10. 32007 /jfacmedbagdad.2145
Hussein LS, Al-Khedairy EBH. Solubility and Dissolution Enhancement of Ebastine by Surface Solid Dispersion Technique. Iraqi J Pharm Sci. 2021;30(1):122-32. https:// doi. org/ 10. 31351/vol30iss1pp122-132
Alkhiro AR, Ghareeb MM. Formulation and evaluation of lornoxicam as dissolving microneedle patch. Iraqi J Pharm Sci. 2020;29(1):184-94. https://doi.org/10.31351/vol29iss1pp184-194
Younus Alkwak RS, Rajab NA. Lornoxicam-Loaded Cubosomes: - Preparation and In vitro Characterization. Iraqi J Pharm Sci. 2022; 31 (1):144-53. https:/ /doi. org/ 10.31351 /vol31 iss1pp144-153
Krosuri P, Reddy YD, Madhavi K, Sunayana J. advances in bioresearch optimization, development, formulation of lornoxicam oral dispersible tablets using central composite experimental design. 2021;12(July):249-56.
Nousheen L, Rajasekaran S, Qureshi MS. Solubility enhancement of lornoxicam with poloxamer 188 by solvent evaporation method. Int J Health Sci (Qassim). 2022;6(March):8186-95. https://doi.org/10.53730/ijhs.v6nS1.6847
Anumolu PD, Sunitha G, Bindu SH, Satheshbabu PR, Subrahmanyam CVS. Development and validation of discriminating and biorelevant dissolution test for lornoxicam tablets. Indian J Pharm Sci. 2015;77(3):312-20. https://doi.org/10.4103/0250-474X.159653
Bao Q, Jog R, Shen J, Newman B, Wang Y, Choi S, et al. Physicochemical attributes and dissolution testing of ophthalmic ointments. Int J Pharm. 2017;523(1):310-9.
Ponnusamy C, Sugumaran A, Krishnaswami V, Palanichamy R, Velayutham R, Natesan S. Development and evaluation of polyvinylpyrrolidone k90 and poloxamer 407 self-assembled nanomicelles: Enhanced topical ocular delivery of artemisinin. Polymers (Basel). 2021;13(18).
Syed S, Syed I, Marathe R. Formulation, development and evaluation of an osmotic drug delivery system for lornoxicam. İstanbul J Pharm. 2023;53(1):10-21.
Fatima K, Bukhari NI, Latif S, Afzal H, Shamim R, Abbas N. Amelioration of physicochemical, pharmaceutical, and pharmacokinetic properties of lornoxicam by cocrystallization with a novel coformer. Drug Dev Ind Pharm. 2021;47(3):498-508. https:// doi.org/10.1080/03639045.2021.1892744
He Y, Majid K, Maqbool M, Hussain T, Mehmood A, Ullah I, et al. Formulation and characterization of lornoxicam-loaded cellulosic- microsponge gel for possible applications in arthritis. Saudi Pharm J. 2020;28(8):994-1003. https:// doi. org /10. 1016/j.jsps.2020.06.021
Shafiq M, Khan BA, Rashid SA, Khan MK, Naseem F, Alqahtani AM, et al. Biodegradable Polymeric Pharmaceutical Nanoemulgel Coloaded with Eucalyptol-Lornoxicam: Fabrication and Characterizations for Possible Better Pain Management. 2023. https:// doi.org /10.1155/2023/4227242
Rai K, Jain V, Jain SK, Khangar PK. Journal of Drug Delivery and Therapeutics Formulation and evaluation of taste masked oral disintegrating tablets of lornoxicam. 2021; 11(5):115-20. https:// doi.org /10. 22270 /jddt. v11i5.5124
Sheth TS, Acharya F. Optimizing similarity factor of in vitro drug release profile for development of early- stage formulation of drug using linear regression model. J Math Ind. 2021;11(1).
Xie F, Ji S, Cheng Z. In vitro dissolution similarity factor (f2) and in vivo bioequivalence criteria, Using a BCS class II drug as a simulation example. Eur J Pharm Sci. 2015;66(October):163-72. http:// dx.doi. org/10 .1016/j.ejps.2014.10.002
Meka AK, Pola S, Tupally KR, Abbaraju PL. Development, evaluation and characterization of surface solid dispersion for solubility and dissolution enhancement of Irbesartan. Int J Drug Dev Re. 2012;4(1):263-73. Available from: http:// dx. doi.org /10. 1016 /j. jopr .2013.06.012
Abduljabbar HH, Abd Alhammid SN. Enhancement of the Solubility and the Dissolution Rate of Tamoxifen Citrate Solid Dispersion Using Soluplus by Solvent Evaporation Technique. Asian J Pharm Clin Res. 2019;12(1): 216.https: //doi.org /10. 22159 /ajpcr .2019.v12i1.28933
Sunitha R, Venugopal K, Satyanarayana S V. Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions. Asian J Pharm. 2021;15(1):115-23.
Content N, Capacity H, Size P. Crospovidone SL. 2017;(16):16-8.
Zarmpi P, Flanagan T, Meehan E, Mann J, Fotaki N. Biopharmaceutical aspects and implications of excipient variability in drug product performance. EurJ PharmBiopharm 2017; 111:1-15. http:// dx.doi. org /10. 1016 /j.ejpb.2016.11.004
Swamy SK, Arun G, Srinivas B, Goud AB. Effect of Various Super Disintegrants on the Drug Release Profile of Orally Disintegrating Tablets. Asian J Pharm Technol. 2016;6(2):99. https://doi.org/10.5958/2231-5713. 2016 .00014 .3
Iso DINEN, Unit V, Safety M, Sheet D, Ag EI. AEROSIL ® 200 Hydrophilic fumed silica Characteristic physicochemical data. 2011; 44(0):44-5.
Teaima MH, Abdel-Haleem KM, Osama R, El-Nabarawi MA, Elnahas OS. A promising single oral disintegrating tablet for co-delivery of pitavastatin calcium and lornoxicam using co-processed excipients: Formulation, characterization and pharmacokinetic study. Drug Des Devel Ther. 2021; 15:4229-42. https://doi.org/10.2147/DDDT.S332729
Dubey BK, Patil S, Sahani V. Formulation and Evaluation of Ibuprofen Mouth Dissolving tablet by using Crospovidone Croscarmellose Sodium. 2023;42(5):582-94.
The United State Pharmacopeia (USP) 39, NF34. Convention Inc. Rockville, MD. 2016
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