Investigate the Factors Influencing the Formulation of Aceclofenac-Loaded Nanosponges Based on Eudragit L100
DOI:
https://doi.org/10.31351/vol35iss1pp41-51Keywords:
nanosponge , aceclofenac ,eudragit l100Abstract
Among the many NSAIDs generated from phenyl acetic acid is Aceclofenac, or ACE. Its antipyretic, analgesic, and anti-inflammatory effects are noteworthy. However, the substance's delayed dissolution, limit permeability, and inadequate bioavailability are caused by its low solubility in water, which hinders its usefulness. Nanosponges (NS) are tiny particles with nanoscale holes and a distinctive three-dimensional nanostructure. The incorporation of both water-soluble and fat-soluble molecules into these hollow spaces enhances the efficacy and safety of medication delivery. This study aims to improve and advance the formulation of ACE-containing nanosponges. The emulsion solvent diffusion procedure is used to prepare the nanosponges that are based on Eudragit L100. The effect of the amounts of polyvinyl alcohol (PVA) and the drug-to-polymer ratio on nanosponge properties are explored. Particle size, product yield, and ACE trapped inside nanosponge percentages are the aspects that be considered during characterization. The results indicated that the product yield and drug entrapment % were significantly reduced as the concentration of Eudragit L100 was increased, while the particle size was significantly increased. A significant change was seen in product yield and entrapment percentage as the PVA content was increased. It also caused a notable increase in particle size. It could be concluded that Eudragit L100 can be used as a polymer matrix to incorporate ACE. In future investigations, ACE would be manufactured as a topical gel.
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