Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release

Authors

  • Ahmed A. Sadon
  • Ahlam J. Qasir

DOI:

https://doi.org/10.31351/vol21iss2pp24-30

Abstract

This study include design and synthesis of 2 derivatives of compounds consisting of mefenamic acid, glycine and organic nitrates (2-nitrooxy ethanol or 1,3-dinitrooxy-2-propanol). Nitric oxide NO has been reported to support many of the same mucosal protection mechanisms as prostaglandins and is sufficient for acute gastroprotection and ulcer healing. So we suppose these 2 compounds would reduce non-steroidal anti-inflammatory drugs NSAIDs gastrointestinal side effect.

Key words: Non-Steroidal anti-inflammatory drugs (NSAIDs), Glycine, Mefenamic acid, Organic nitrates, Nitric oxide (NO).

Published

2017-03-29

Issue

Vol. 21 No. 2 (2012): Iraqi J Pharm Sci, Vol.21(2) 2012

Section

Article

License

Copyright (c) 2017 Iraqi Journal of Pharmaceutical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

1.
A. Sadon A, J. Qasir A. Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2017 Mar. 29 [cited 2024 Nov. 5];21(2):24-30. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/455

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