Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors
DOI:
https://doi.org/10.31351/vol28iss2pp151-158Keywords:
primary amides, HDACIs, adipic monoanilide amide, pimelic monoanilide amideAbstract
Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.
Received: 31/ 5 /2019
Accepted: 21/8 / 2019
How to Cite
1.
Al-Amily D, Mohammed MH. Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2019 Dec. 23 [cited 2024 Dec. 23];28(2):151-8. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/933
