Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives
DOI:
https://doi.org/10.31351/vol28iss1pp106-112Keywords:
: Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method.Abstract
Three new hydrazone derivatives of Etodolac were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy, and 1HNMR analysis. The synthesis of the target (P1-P3) compounds was accomplished following multistep reaction procedures. The synthesized target compounds were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac).
How to Cite
1.
M. Hassan O, W. Sarsam S. Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2019 Jun. 9 [cited 2024 Dec. 23];28(1):106-12. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/942
