Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity

Authors

  • Ali M. Al-joda
  • Munaf H. Zalzala College of pharmacy/ University of Baghdad

DOI:

https://doi.org/10.31351/vol28iss2pp180-185

Abstract

Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary tract cells. Guggulsterone is a sterol derived from plant has ability to bind to farsenoid X receptor, mineral corticosteroid receptor, androgen receptor, glucocorticoid receptor and estrogen receptor.

How to Cite

1.
M. Al-joda A, Zalzala MH. Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2019 Dec. 23 [cited 2024 Dec. 24];28(2):180-5. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/960

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Published

2019-12-23