Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Fenoprofen Hydrazone Derivatives

Authors

  • Hayder M. Abdulhamza college of pharmacy
  • Muthanna S. Farhan

DOI:

https://doi.org/10.31351/vol29iss2pp239-244

Keywords:

Keywords: Fenoprofen hydrozone derivatives, Anti-inflammatory, Paw edema method

Abstract

New hydrazone derivatives of Fenoprofen were synthesized and evaluated for their anti-inflammatory activity by means of egg white induced paw edema method. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis and by measure of their physical properties. The synthesis of the target compounds(H1-H4) was accomplished by multistep reaction procedures. The synthesized target compounds were show activity in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Fenoprofen) except for compound H3 which show anti-inflammatory activity higher than Fenoprofen.

How to Cite

1.
Abdulhamza HM, S. Farhan M. Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Fenoprofen Hydrazone Derivatives. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2020 Dec. 30 [cited 2024 Nov. 21];29(2):239-44. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1117

Publication Dates

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Published

2020-12-30