Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Fenoprofen Hydrazone Derivatives
DOI:
https://doi.org/10.31351/vol29iss2pp239-244Keywords:
Keywords: Fenoprofen hydrozone derivatives, Anti-inflammatory, Paw edema methodAbstract
New hydrazone derivatives of Fenoprofen were synthesized and evaluated for their anti-inflammatory activity by means of egg white induced paw edema method. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis and by measure of their physical properties. The synthesis of the target compounds(H1-H4) was accomplished by multistep reaction procedures. The synthesized target compounds were show activity in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Fenoprofen) except for compound H3 which show anti-inflammatory activity higher than Fenoprofen.
Received: 20/ 2/2020
Accepted: 9/8 /2020
How to Cite
1.
Abdulhamza HM, S. Farhan M. Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Fenoprofen Hydrazone Derivatives. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2020 Dec. 30 [cited 2024 Nov. 22];29(2):239-44. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1117
