Synthesis, Characterization and Antibacterial Evaluation of Some Coumarin Derivatives
DOI:
https://doi.org/10.31351/vol30iss1pp249-257Keywords:
Coumarin, hydrazones, amide, antibacterial, well diffusion method.Abstract
Coumarin derivatives have shown different biological activities, such as antifungal, antibacterial antiinflammatory, and antioxidant activities, besides antibiotic resistance modulating effects, and anti-HIV, hepatoprotective, and antitumor effect. So, new coumarin derivatives (hydrazones and an amide) were synthesized through multisteps reactions. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis. The compounds then evaluated for their anti-bacterial activity by means of well-diffusion method against two gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae) and two gram-negative bacteria (E.coli and Pseudomonas aeruginosa). The highest activity was demonstrate by compound k2 which found to be highly active against pseudomonas aeruginosa.
Received: 13/9/2020
Accepted:16 /1 /2020
