The Safranal Effect against Cyclophosphamide-Induced Liver Injury

Authors

  • Munaf Hashim Zalzala College of pharmacy/ University of Baghdad
  • Victoria S. Kareem

DOI:

https://doi.org/10.31351/vol30iss2pp208-213

Keywords:

liver toxicity, cyclophosamide, safranal, glutathione, NRF2

Abstract

The liver is the primary organ for drug metabolism, elimination, Cyclophosphamid is the classical alkylating agent nitrogen mustard, its metabolism into two cytotoxic metabolites, and increase reactive oxygen species that is make liver toxicity. Safranal as the most abundant chemical in saffron essential oil, it have anti-oxidant, anti-inflammatory, antiapoptic and free radical scavenger activity. The aim of study is to assess the protective effects of safranal on the cyclophosphamide-induce liver toxicity in rat model. This occur by using five different groups of rats; control group, treatment group, cyclophosamide group (intraperitoneal i.p), cyclophosamide and (50mg and 100mg) oral safranal treatment groups. This study showed this protective by decreasing liver parameter enzyme (aminotransferase enzyme) and MDA level, increases glutathione and NRF2

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Published

2021-12-11

How to Cite

1.
Zalzala MH, S. Kareem V. The Safranal Effect against Cyclophosphamide-Induced Liver Injury. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2021 Dec. 11 [cited 2024 Nov. 5];30(2):208-13. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1335