Impact of Clinical Pharmacist-Led Interventions on Short Term Quality of Life among Breast Cancer Women Taking Chemotherapy
DOI:
https://doi.org/10.31351/vol33iss4pp165-172Keywords:
Chemotherapy, Pharmacist- led interventions, quality of life, pharmaceutical care, Adverse effectsAbstract
Abstract:
Background: Drug toxicity and chemotherapeutic side effects negatively impact the quality of life of breast cancer patients.
Objectives: to evaluate the efficacy of pharmaceutical Interventions (PI) on quality of life (QOL)Among chemotherapy intake breast cancer women.
Method: A pre-post interventional study was carried out at the chemotherapy ward of Alhabobi Hospital in Alnasiriyah City. Eligible patients received comprehensive pharmaceutical care and a self-compiled Breast Cancer Patients Medication Knowledge Guide pamphlet. Each patient received two sessions, the first at baseline and the second after 7, 14, or 21 days depending on the next taking dose of chemotherapy. Each session lasted for approximately 15-30 minutes. Participants were asked to complete a QOL Questionnaire(EORTC QLQ-C30) before and after study time.
Results: Fifty women with breast cancer were enrolled in the interventional group, and all of these patients ultimately completed the study, at the end of the study, the five functional scales (physical, role, emotional, cognitive, and social), were significantly increased after the intervention by the clinical pharmacist. The three symptom scales (fatigue, nausea/vomiting, and pain) were significantly decreased after the study. In addition, six individual measurement project scores were decreased at the end of the study. However, constipation was the only intervention that had no effect.
Conclusion: a clinical pharmacist-led educational intervention may enhance the quality of life of breast cancer patients and play a crucial role in reducing chemotherapy-related complications and adverse effects.
How to Cite
Publication Dates
Received
Revised
Accepted
Published Online First
References
Ahmed AAR. Awareness of breast cancer among university female students in Baghdad. AL-Kindy Coll Med J [Internet]. 2019 Sep 11 [cited 2023 Sep 22];15(1):6–14. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/67
Alwan NAS, Tawfeeq FN, Muallah FH. Breast Cancer Subtypes among Iraqi Patients: Identified By Their ER, PR and HER2 Status. J Fac Med Baghdad [Internet]. 2018 Jan 2 [cited 2023 Sep 22];59(4):303–7. Available from: https:// iqjmc .uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/69
Abdulwahid hiba mohammed. Comparison between Mammography and Breast Ultrasound in the Detection of Breast Cancer in Dense Breast Tissue among a Sample of Iraqi Women. J Fac Med Baghdad [Internet]. 2019 Jul 29 [cited 2023 Aug 31];61(1):25–9. Available from: https:// iqjmc. uobaghdad. edu.iq/ index. php /19JFacMedBaghdad36/article/view/889
Abood RA, Abdahmed KA, Mazyed SS. Epidemiology of Different Types of Cancers Reported in Basra, Iraq. Sultan Qaboos Univ Med J [SQUMJ] [Internet]. 2020 Oct 5 [cited 2023 Sep 22];20(3):295. Available from: https://pubmed.ncbi.nlm.nih.gov/33110644/
Sharma A, Thomas J, Bairy K, Kumari Km, Manohar H. Pattern of adverse drug reactions due to cancer chemotherapy in a tertiary care hospital in South India. Perspect Clin Res [Internet]. 2015 [cited 2023 Aug 28];6(2):109. Available from: http://www. picronline .org/ text. asp?2015/6/2/109/154014
Shihab IK, H. Mohammed M. Synthesis, Characterization and Preliminary Anticancer Study of Novel 5-fluorouracil Conjugate with Pyrrolidine Dithiocarbamate as a Mutual Anticancer Prodrug. Iraqi J Pharm Sci ( P-ISSN 1683 - 3597 , E-ISSN 2521 - 3512) [Internet]. 2019 Dec 21 [cited 2023 Sep 22];28(2):17–23. Available from: https:// bijps. uobaghdad. edu. iq/ index.php/bijps/article/view/874
Osanlou R, Walker L, Hughes DA, Burnside G, Pirmohamed M. Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions. BMJ Open [Internet]. 2022 Jul 4 [cited 2023 Oct 18];12(7):e055551. Available from: https:// pubmed. ncbi.nlm.nih.gov/35788071/
Kimmick GG, Li X, Fleming ST, Sabatino SA, Wilson JF, Lipscomb J, et al. Risk of cancer death by comorbidity severity and use of adjuvant chemotherapy among women with locoregional breast cancer. J Geriatr Oncol [Internet]. 2018 May 1 [cited 2023 Aug 28];9(3):214–20. Available from: https:// consensus. app/details/breast-cancer-patients-comorbidity-increased-risk-dying-kimmick/ 00095f5472cf53539d222752955670fe/
Xu F. Informing Patients About Drug Effects Using Positive Suggestion. J Manag Care Pharm [Internet]. 2008 May [cited 2023 Apr 18];14(4):395–6. Available from: https:// pubmed. cbi.nlm.nih.gov/18500917/
Krishnarajan D, Sivasakthi K, Ariyamol R, Kumar Dn, Varghese S. A prospective observational study of chemotherapy-induced adverse drug reaction and the quality of life in cancer patients in a tertiary care hospital. J Cancer Res Ther [Internet]. 2021 Apr 1 [cited 2023 Oct 17];17(2):530. Available from: https://pubmed.ncbi.nlm.nih.gov/34121703/
Pereira I, Pereira M, Leite Â, Pereira MG. Quality of Life in Women With Breast Cancer Receiving Chemotherapy and the Moderating Role of Cortisol. Cancer Nurs [Internet]. 2022 Nov 1 [cited 2023 Oct 17];45(6):E856–64. Available from: https://pubmed. ncbi.nlm.nih. gov/35324503/
Poort H, Jacobs JM, Pirl WF, Temel JS, Greer JA. Fatigue in patients on oral targeted or chemotherapy for cancer and associations with anxiety, depression, and quality of life. Palliat Support Care [Internet]. 2020 Apr 19 [cited 2023 Oct 17];18(2):141–7. Available from: https://pubmed.ncbi.nlm.nih.gov/31535613/
Lewandowska A, Rudzki G, Lewandowski T, Próchnicki M, Rudzki S, Laskowska B, et al. Quality of Life of Cancer Patients Treated with Chemotherapy. Int J Environ Res Public Health [Internet]. 2020 Sep 23 [cited 2023 Oct 19];17(19):6938. Available from: https:// pubmed.ncbi.nlm.nih.gov/32977386/
Ajoob RD., Hassani HS, Abudlhameed JR. Surgical –Audit on breast cancer risk factors in AL-Russafa district in Baghdad. AL-Kindy Coll Med J [Internet]. 2015 Jun 30 [cited 2023 Oct 22];11(1):73–7. Available from: https:// jkmc. uobaghdad .edu.iq/index. php/MEDICAL /article /view/414
Wang Y, Wu H, Xu F. Impact of Clinical Pharmacy Services on KAP and QOL in Cancer Patients: A Single-Center Experience. Biomed Res Int [Internet]. 2015 [cited 2023 Sep 22];2015:1–8. Available from: https:// pubmed. ncbi. nlm.nih.gov/26697487/
Fayers P, NK A, K B, M G, D C, A B. EORTC QLQ-C30 Scoring Manual The EORTC QLQ-C30 Introduction. EORTC QLQ-C30 Scoring Man [Internet]. 2001;30:1–67. Available from: http:// www .eortc.be/qol/files/scmanualqlq-c30 .pdf
National Cancer Institute. Chemotherapy and you. US Dep Heal Hum Serv | Natl Institutes Heal [Internet]. 2018;68. Available from: http://www.cancer.gov/cancertopics/coping/chemotherapy-and-you
Dicato MA, Van Cutsem E. Side effects of medical cancer therapy: Prevention and treatment: Second edition. Side Eff Med Cancer Ther Prev Treat Second Ed. 2018 Jun 27;1–513.
Marian M, Roberts S. Clinical Nutrition for Oncology Patients. Jones Bartlett Publ [Internet]. 2010 [cited 2023 Oct 5];1–243. Available from: https://www.jblearning.com/catalog
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. JNCI J Natl Cancer Inst [Internet]. 1993 Mar 3 [cited 2023 Feb 22];85(5):365–76. Available from: https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/85.5.365
Silveira FM, Wysocki AD, Mendez RDR, Pena SB, Santos EM dos, Malaguti-Toffano S, et al. Impacto do tratamento quimioterápico na qualidade de vida de pacientes oncológicos. Acta Paul Enferm [Internet]. 2021 Jun 29;34. Available from: https://acta-ape.org/ article/ impacto-do-tratamento-quimioterapico-na-qualidade-de-vida-de-pacientes-oncologicos/
Neves Duarte Lisboa I, Dantas de Sá Tinôco J, Dias Fernandes MI da C, da Silva RR, Student N, Barbosa da Silva J, et al. Constipation in Chemotherapy Patients: A Diagnostic Accuracy Study. Asian Pacific J Cancer Prev [Internet]. 2021 Sep 1 [cited 2023 Oct 19];22(9):3017–21. Available from: https://pubmed .ncbi. nlm. nih. gov/34582674/
Yurtdaş G, Acar-Tek N, Akbulut G, Cemali Ö, Arslan N, Beyaz Coşkun A, et al. Risk Factors for Constipation in Adults: A Cross-Sectional Study. J Am Coll Nutr [Internet]. 2020 Nov 16 [cited 2023 Oct 19];39(8):713–9. Available from: https:// pubmed. ncbi. nlm. nih. gov/ 32077808/
Ryan K, Johnston BM, McAleer C, O’Connor L, Larkin P. A national cross-sectional survey of constipation in patients attending cancer centres in Ireland. HRB Open Res [Internet]. 2022 [cited 2023 Oct 22];4. Available from: https:// pubmed. ncbi .nlm.nih.gov/36311471/
Jabarah MAH. Quality of life in capecitabine-treated patients with colorectal cancer is affected by their sociodemographic characteristics and their experience of the drug-related adverse effects. J Fac Med Baghdad [Internet]. 2022 Oct 17 [cited 2023 Oct 19];64(3):175–82. Available from: https:// iqjmc. uobaghdad. edu.iq /index. php/ 9JFacMedBaghdad36/article/view/1970
Rajindrajith S, Ranathunga N, Jayawickrama N, van Dijk M, Benninga MA, Devanarayana NM. Behavioral and emotional problems in adolescents with constipation and their association with quality of life. Olino TM, editor. PLoS One [Internet]. 2020 Oct 12 [cited 2023 Aug 30];15(10):e0239092. Available from: https://dx.plos.org/10.1371/journal.pone.0239092
Mohammed SI, Sabry AT, Sabry DT. Assessment of Health Beliefs Among Iraqi Breast Cancer Patients in Baghdad using either Tamoxifen or Trastuzumab. Iraqi J Pharm Sci ( P-ISSN 1683 - 3597 , E-ISSN 2521 - 3512) [Internet]. 2021 Dec 11 [cited 2023 Aug 31];30(2):113–21. Available from: https:// bijps. uobaghdad. edu.iq/index .php/bijps/article /view/1311
I. Rasheed J, M. Abbas H. Implementation of a Clinical Pharmacy Training Program in Iraqi Teaching Hospitals : Review Article. Iraqi J Pharm Sci ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) [Internet]. 2017 Mar 28 [cited 2023 Sep 7];21(1):1–5. Available from: https:// bijps. uobaghdad. edu.iq/index. php/ bijps /article /view/433
Liu L, Rissling M, Natarajan L, Fiorentino L, Mills PJ, Dimsdale JE, et al. The Longitudinal Relationship between Fatigue and Sleep in Breast Cancer Patients Undergoing Chemotherapy. Sleep [Internet]. 2012 Feb 1 [cited 2023 Aug 30];35(2):237–45. Available from: https://academic.oup.com/sleep/article-lookup / doi/10.5665/sleep.1630
Davidson JR. Boosting access to insomnia treatment for cancer patients. Sleep [Internet]. 2014 Aug 1 [cited 2023 Jun 9];37(8):1277–8. Available from: https://pubmed .ncbi.nlm.nih. gov/25083005/
Savard J, Ivers H, Savard MH, Morin CM. Is a video-based cognitive behavioral therapy for insomnia as efficacious as a professionally administered treatment in breast cancer? Results of a randomized controlled trial. Sleep [Internet]. 2014 Aug 1 [cited 2023 Jun 9];37(8):1305–14. Available from: https:// pubmed. ncbi. nlm. nih. gov/25083010/
Mustian KM. Yoga as Treatment for Insomnia Among Cancer Patients and Survivors: A Systematic Review. Eur Med journal Oncol [Internet]. 2013 Nov 1 [cited 2023 Oct 22];1:106–15. Available from: https:// pubmed. ncbi. nlm.nih.gov/25343044/
Savard J, Ivers H, Villa J, Caplette-Gingras A, Morin CM. Natural Course of Insomnia Comorbid With Cancer: An 18-Month Longitudinal Study. J Clin Oncol [Internet]. 2011 Sep 10 [cited 2023 Jun 9];29(26):3580–6. Available from: https:// ascopubs .org/ doi/ 10. 1200 /JCO.2010.33.2247
Kwekkeboom KL, Cherwin CH, Lee JW, Wanta B. Mind-body treatments for the pain-fatigue-sleep disturbance symptom cluster in persons with cancer. J Pain Symptom Manage [Internet]. 2010 Jan [cited 2023 Jun 9];39(1):126–38. Available from: https:// pubmed. ncbi. nlm.nih. gov/ 9900778/
Mohammed SI, Dawood EB, Abaas IS. Perceptions and attitudes of community pharmacists towards patient counseling and continuing pharmacy education programs in Iraq. Iraqi J Pharm Sci ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) [Internet]. 2019 Dec 22 [cited 2023 Sep 22];28(2):30–6. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/879
Roscoe JA, Morrow GR, Aapro MS, Molassiotis A, Olver I. Anticipatory nausea and vomiting. Support Care Cancer [Internet]. 2011 Oct [cited 2023 Jun 9];19(10):1533–8. Available from: https:// pubmed. ncbi.nlm. nih.gov /20803345/
Redd WH, Montgomery GH, DuHamel KN. Behavioral Intervention for Cancer Treatment Side Effects. JNCI J Natl Cancer Inst [Internet]. 2001 Jun 6 [cited 2023 Sep 16];93(11):810–23. Available from: https:// academic .oup. com /jnci/article-lookup/doi/10.1093/jnci/93.11.810
Do J, Cho Y, Jeon J. Effects of a 4-Week Multimodal Rehabilitation Program on Quality of Life, Cardiopulmonary Function, and Fatigue in Breast Cancer Patients. J Breast Cancer [Internet]. 2015 Mar 1 [cited 2023 Jun 9];18(1):87. Available from: https:// ejbc .kr/ DOIx. php?id=10.4048/jbc.2015.18.1.87
Yun YH, Lee KS, Kim YW, Park SY, Lee ES, Noh DY, et al. Web-based tailored education program for disease-free cancer survivors with cancer-related fatigue: a randomized controlled trial. J Clin Oncol [Internet]. 2012 Apr 20 [cited 2023 Jun 9];30(12):1296–303. Available from: https:// pubmed. ncbi.nlm. nih.gov /22412149/
Naeem F, Gobbi M, Ayub M, Kingdon D. Psychologists experience of cognitive behaviour therapy in a developing country: a qualitative study from Pakistan. Int J Ment Health Syst [Internet]. 2010 Jan 28 [cited 2023 Jun 9];4(1):2. Available from: http://ijmhs. biomedcentral. com/articles/10.1186/1752-4458-4-2
de Freitas Maniva SJC, de Freitas CHA, Jorge MSB, de Figueiredo Carvalho ZM, Moreira TMM. [Quality of life in hematologic oncology patients undergoing chemotherapy]. Rev Esc Enferm USP [Internet]. 2013 [cited 2023 Oct 23];47(2):357–63. Available from: https:// pubmed. ncbi.nlm.nih.gov/23743901/
Moukafih B, Abahssain H, Mrabti H, Errihani H, Rahali Y, Taoufik J, et al. Impact of clinical pharmacy services in a hematology/oncology ward in Morocco. J Oncol Pharm Pract [Internet]. 2021 Mar 23 [cited 2023 Jun 10];27(2):305–11. Available from: http: // journals. sagepub.com /doi/10.1177/ 10781552- 20919169
Khazal AA, Jamal MY. Pharmacist Intervention to Address Drug Related Problems in Patients with Decompensated Liver Cirrhosis. Al-Kindy Coll Med J [Internet]. 2023 Apr 30 [cited 2023 Aug 31];19(1):121–6. Available from: https:// www. researchgate .net/ publication/ 370423295 _Pharmacist _Intervention _to_ Address _Drug _Related_Problems_in_Patients_with_Decompensated_Liver_Cirrhosis
Khoshnood Z, Dehghan M, Iranmanesh S, Rayyani M. Informational Needs of Patients with Cancer: A Qualitative Content Analysis. Asian Pac J Cancer Prev [Internet]. 2019 Feb 1 [cited 2023 Aug 30];20(2):557–62. Available from: https:// consensus. app / details /results - showed-patients - cancer -tended -cancer -ways-cancer-khoshnood / cb 42c08795a 455 cae90 053d73a 606cc/
Jassim GA, Doherty S, Whitford DL, Khashan AS. Psychological interventions for women with non-metastatic breast cancer. Cochrane Database Syst Rev [Internet]. 2023 Jan 11 [cited 2023 Oct 6];2023(1). Available from: https:// www. cochranelibrary .com/cdsr /doi/10. 1002/ 14651858.CD008729.pub3/full
Downloads
Published
License
Copyright (c) 2024 Iraqi Journal of Pharmaceutical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
