Design, Synthesis, Characterization and Comparative Cytotoxic Evaluation of bis-(2- mercaptoacetate) gold (III) chloride

Abstract

In recent years , the interest in gold (III) species have gained more and more attention for cancer chemotherapy , this was stimulating by the possibility to develop new agents with mode of action and clinical profile different from the established platinum metalodrugs.

With this frame, recently new square planar Au(III)  complexes (Au(L)(L')_n); where L=SCH₂COO^- ; L'=HSCH₂COO^- had been synthesized with S/O – donor ligands.

In this article and by the aim to replace, one of (L') ligand by anion chloride ligand (which supposedly more relevant for the biodistribution of the compound than for its pharmacodynamic effects), new complex (Au(L')₂ Cl) was synthesized :

         (H (AuCl₄) + 2 HSCH₂COO ^-Na⁺                                                          Au(L')₂ Cl)          

The prepared complex was characterized by elemental analysis, FTIR, H'NMR, UV,  molar conductance and magnetic susceptibility and its anticancer activity was tested against Hep-2 cell line.

   The comparative figure  of the cytotoxic activities  of all the synthesized complexes against Hep-2 cell line , showed cytotoxic profile variant to  the well- known anticancer drug cisplatin , indicated that there is no direct correlation exists between the nature of the ligands (L),(L') and (Cl^-)  , their different arrangements around central metal core with their  collectives cytotoxic results. 

Key words: S/O – donor ligands. , gold (III), cytotoxic