Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA)

Abstract

         Recurrent Spontaneous Abortion (RSA) is the most painful experience for couples expecting a child. This study aimed to determine the relevance of IL-2 and IL-6 in recurrent spontaneous abortion (RSA).  Serum samples were collected from 90 women attend Al Kadhmiya teaching hospital in Baghdad. 60 women (first group) had recurrent abortion the women were negative for rubella virus, herpes simplex virus and toxplasma gondii. And they were negative from bacterial infection eg. Niesseria gonorrhea and Chlamydia trachomatis. The histopathological tests for fetus abnormalities were negative in this group, and 30 women (second group) with successful pregnancy (normal delivery). All samples were analyzed for IL-2 and IL-6 by commercially available Enzyme-Linked Immunosorbent Assay (ELISA) kits. The data showed highly significant increase in the serum level of IL-2 in group 1 compared with group 2 (P<0.001). However, IL-6 showed highly significant increase level in group 2 compared with group 1. In addition, there was no significant correlation between these two markers in studied groups. The data of this study strengthen the possibility that high level of IL-2 and low level of IL-6 may explain the role of type-1 cytokines in the pathogenicity of recurrent spontaneous abortion.

Key words: - interleukin 2, interleukin 6 and  recurrent spontaneous abortion (RSA)