The Release of Diazepam from Different Conventional and Hollow Type Suppository Bases

Authors

  • Balkis A. Kamal

DOI:

https://doi.org/10.31351/vol16iss2pp21-26

Abstract

The objective of this study was to investigate the release profile of different fat and water soluble bases using diazepam as a model drug , and then to develop  a satisfactory formula with a rapid release of diazepam from suppository bases .The study was conducted using theobroma oil ,glycerol-gelatin and glycerol-PEG1540 bases using conventional mold method for preparation .while the later base was utilized to incorporate diazepam ( buffered solution ) in a hollow type suppositories. The results indicated that all types of bases can be utilized to formulate diazepam as  rectal suppositories with acceptable disintegration time ( 12, 10, 6, and 6min.), respectively . While 100% of the  released drug had been shown different release profiles with different storage time ( 15, 30, and 45 days ) in a refrigerator at 5°C , best results were obtained , when glycerol- PEG1540 used as a base for both conventional and hollow type mold methods .However , a decrease in the release rate of the drug was seen with glycerol-gelatin and glycerol-PEG1540 and to a lesser extent for glycerol-PEG1540 prepared

by hollow type method .

Key words:  Diazepam  , Hollow type suppository

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Published

2017-03-30

How to Cite

1.
A. Kamal B. The Release of Diazepam from Different Conventional and Hollow Type Suppository Bases. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2017 Mar. 30 [cited 2024 Nov. 12];16(2):21-6. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/585