Preparation and characterization of timed drug delivery system of sumatriptan using natural polymers

Authors

  • Mina Shihab Al-anbagi Baghdad
  • Nawal A. Rajab
  • Yehia I.Khalil

DOI:

https://doi.org/10.31351/vol27iss1pp89-99

Keywords:

Pulsatile, Sumatriptan, Migraine. Pectin, Ethyl cellulose, Hydroxypropylmethylcellulose.

Abstract

Pulsatile drug delivery systems are time-controlled dosage forms which are designed to release the active pharmaceutical ingredient after a predetermined lag time to synchronize the disease circadian rhythm. A migraine shows circadian rhythm with a marked increase in attacks between 6 a.m. and 8 a.m.

Sumatriptan is a selective agonist at serotonin (5-Hydroxy tryptamine1  (5-HT1))receptors, is an effective treatment for acute migraine attacks.

The aim of this work is to prepare time-controlled press-coated tablet with a lag time of 5.45 hrs.

Six formulas of fast dissolving core tablets and three formulas of press-coated tablets were prepared by using direct compression method using different variables to prepare core tablets which include: different types and concentrations of superdisintegrants While different concentrations of natural and synthetic polymers were utilized in the preparation of press-coated tablets.

The obtained results showed that formula  F4 of core tablet, which contained 25 mg of sumatriptan, 5% w/w sodium starch glycolate and avicel PH 102 as the diluent, was the selected formula that gave the fastest and complete release of sumatriptan. Also, formula C3 of the press-coated tablet, which contained pectin: EC100 mpa.s: HPMCK15M in concentration30mg: 10mg:160mg respectively, was selected as the best coating layer since it gave 5.45  hours lag time.

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Published

2018-06-05

How to Cite

1.
Al-anbagi MS, A. Rajab N, I.Khalil Y. Preparation and characterization of timed drug delivery system of sumatriptan using natural polymers. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2018 Jun. 5 [cited 2024 Nov. 5];27(1):89-9. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/754

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