Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel

Authors

  • Maysam M. Abass baghdad college of pharmacy
  • Nawal A. Rajab

DOI:

https://doi.org/10.31351/vol28iss1pp64-74

Abstract

Nanosponges (NS) of etodolac(ETO) was prepared using the emulsion solvent diffusion method ; the effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and characterized, The selected formula was lyophilized then incorporated into hydrogel ; which also evaluated .The results show that the formulation that contain Drug: PVA:EC in ratio 1:3:2 is the best with smallest particle size 40.2±0.098 with polydispersibility0.005 and in vitro release 97.6±0.11%, , ETO NS Carbopol hydrogel produced a significant(p<0.05) improvement of the in vitro release than pure ETO hydrogel.

Received:8 / 9/2018

Accepted: 14/11/2018

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Published

2019-06-11

Issue

Vol. 28 No. 1 (2019): Iraqi J Pharm Sci

Section

Article

How to Cite

1.
Abass MM, A. Rajab N. Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2019 Jun. 11 [cited 2024 Nov. 5];28(1):64-7. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/824

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