Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique

Authors

  • Ahmed S. Abdul Jabbar

DOI:

https://doi.org/10.31351/vol27iss1pp20-29A

Abstract

The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone  s630 was utilized. The HME raltegravir was formulated into tablet by direct compression method. The prepared tablets were assessed for all pre and post-compression parameters. The drug- excipients interaction was examined by FTIR and DSC. All formulas displayed complying with pharmacopoeial measures. The study reveals that formula prepared by utilizing drug and plasdone S630 at 1:1.5 proportion and span 20 at concentration about 30mg (trail-6) has given highest dissolution rate than contrasted with various formulas of raltegravir.

Keywords: Hot melt extrusion, Raltegravir, Plasdone S630.

Downloads

Published

2018-06-04

Issue

Vol. 27 No. 1 (2018): Iraqi J Pharm Sci

Section

Article

How to Cite

1.
S. Abdul Jabbar A. Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2018 Jun. 4 [cited 2024 Nov. 5];27(1):20-29A. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/768