Preparation and Characterization of Topical Letrozole Nanoemulsion for Breast Cancer

Authors

  • Ihab D. Hammodi Baghdad university
  • Shaimaa N. Abd Alhammid

DOI:

https://doi.org/10.31351/vol29iss1pp195-206

Abstract

Letrozole (LZL) is a non-steroidal competitive aromatase enzyme system inhibitor. The aim of this study is to improve the permeation of LZL through the skin by preparing as nanoemulsion using various numbers of oils, surfactants and co-surfactant with deionized water. Based on solubility studies, mixtures of oleic acid oil and tween 80/ transcutol p as surfactant/co-surfactant (Smix) in different percentages were used to prepare nanoemulsions (NS). Therefore, 9 formulae of (o/w) LZL NS were formulated, then pseudo-ternary phase diagram was used as a useful tool to evaluate the NS domain at Smix ratios: 1:1, 2:1 and 3:1.

Received: 13/ 9/2019

Accepted: 12/ 1 /2020

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Published

2020-06-25

Issue

Vol. 29 No. 1 (2020): Iraqi J Pharm Sci

Section

Article

How to Cite

1.
Hammodi ID, N. Abd Alhammid S. Preparation and Characterization of Topical Letrozole Nanoemulsion for Breast Cancer. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2020 Jun. 25 [cited 2024 Nov. 5];29(1):195-206. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/989