Estimation of NESFATIN-1 and VEGFA Levels in Iraqi Celiac Disease Patients Infected with Helicobacter pylori
DOI:
https://doi.org/10.31351/vol33iss2pp31-35Keywords:
Celiac disease, Helicobacter pylori, vascular endothelial growth factor A (VEGFA), Nesfatin-1.Abstract
Celiac disease is an autoimmune disease. It is associated with atrophy of the intestinal villi, leading to reduced absorbed nutrients. Nesfatin-1 is a peptide that is used as a laboratory detection tool in CD detection. VEGF plays a role in the permeability of endothelial functions. Helicobacter pylori are colonized and cause stomach injury in adults and children. H. pylori are cause chronic gastritis, duodenal ulcers, and adenocarcinomas. The study was estimated the NESFATIN-1 and VEGFA in CD with H. pylori. (41) CD with H. pylori and (31) CD without H. pylori, (42) control group is included in the study. Nesfatin-1 and VEGFA were measured in the entire participant. Nesfatin-1 was higher in CD than in the control group. It was lower in men than women and lowered in persons under 35 years of age than in persons over 35 years of age. VEGF was higher in patients with CD, it was higher in men than in women, and higher in persons less than 35 years of age than in persons with more than 35 years of age; also, it was higher in less than 35 years of age than in more than 35 years of age, a high level of VEGFA was detected in CD. VEGF expression change is reported in some tumors; it is unsuitable for detecting celiac disease but can be used for patients' follow-ups. CD cases have higher nesfatin-1 levels than in IBS-D or the control group. Deficiencies of minerals and vitamins are detected in CD patients irrespective of age and gender. All CD cases had nutritional deficiencies.
Received 1/3/2023
Accepted 8/5/2023
Published 27/6/2024
How to Cite
Publication Dates
References
Serena G, D'Avino P and Fasano A. Celiac Disease and Non-Celiac Wheat Sensitivity: State of Art of Non-Dietary Therapies. Front. Nutr. (2020), 7:152. doi: 10.3389/ fnut.2020 .00152
Leonard MM, Sapone A, Catassi C, Fasano A. Celiac disease and nonceliac gluten sensitivity: a review. JAMA. (2017) 318:647–56. doi: 10. 1001 /jama.2017.9730
Spijkerman, M.; Tan, I.L.; Kolkman, J.J.; Withoff, S.; Wijmenga, C.; Visschedijk, M.C.; Weersma, R.K. A large variety of clinical features and concomitant disorders in celiac disease—A cohort study in The Netherlands.Dig. Liver Dis. (2016), 48, 499–505.
Al-Toma, A.; Volta, U.; Auricchio, R.; Castillejo, G.; Sanders, D.S.; Cellier, C.; Mulder, C.J.; Lundin, K.E.A. European society for the study of coeliac disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United Eur. Gastroenterol. J. (2019), 7, 583–613.
Husby, S.; Koletzko, S.; Korponay-Szabó, I.; Kurppa, K.; Mearin enter, M.L.; Ribes-Koninckx, C.; Shamir, R.; Troncone, R.; Auricchio, R.; Castillejo, G.; et al. European society paediatric gastro ology, hepatology and nutrition guidelines for diagnosing coeliac disease J. Pediatr. Gastroenterol. Nutr. 2020, 70, 141–156.
Pelkowski TD, Viera AJ. Celiac disease: diagnosis and management. Am Fam Physician. 2014, 15;89(2):99-105. PMID: 24444577.
Fuchs, V.; Kurppa, K.; Huhtala, H.; Mäki, M.; Kekkonen, L.; Kaukinen, K. Delayed celiac disease diagnosis predisposes to reduced quality of life and incremental use of health care services and medicines: A prospective nationwide study. United Eur. Gastroenterol. J. 2018, 6, 567–575.
Parzanese, I.; Qehajaj, D.; Patrinicola, F.; Aralica, M.; Chiriva-Internati, M.; Stifter, S.; Elli, L.; Grizzi, F. Celiac disease: From pathophysiology to treatment. World J. Gastrointest Pathophysiol. 2017, 8, 27–38.
Mooney, P.D.; Evans, K.E.; Singh, S.; Sanders, D.S. Treatment failure in coeliac disease: A practical guide to investigation and treatment of non-responsive and refractory coeliac disease. J. Gastrointest. Liver Dis. 2012, 21, 197–203.
Caio, G.; Volta, U.; Sapone, A.; Leffler, D.A.; de Giorgio, R.; Catassi, C.; Fasano, A. Celiac disease: A comprehensive current review. BMC Med. 2019, 17, 142.
Di Nardo, G.; Villa, M.P.; Conti, L.; Ranucci, G.; Pacchiarotti, C.; Principessa, L.; Raucci, U.; Parisi, P. Nutritional deficiencies in children with celiac disease resulting from a gluten-free diet: A systematic review. Nutrients 2019, 11, 1588.
Kikut, J.; Konecka, N.; Szczuko, M. Quantitative assessment of nutrition and nutritional status of patients with celiac disease aged 13–18. Rocz. Panstw. Zakl. Hig. 2019, 70, 359–367.
Nicolette J. Wierdsma, Marian A.E. van Bokhorst-de van der Schueren, Marijke Berkenpas, Chris J.J.Mulder and Ad A. van Bodegraven, Vitamin and mineral deficiency are prevalent in newly diagnosed celiac disease patients, Nutrients 2013, 5, 3975-3992.
Karatay E, Gül-Utku Ö, Aksoy N. The Performance of Nesfatin-1 in Distinguishing Irritable Bowel Syndrome Presenting Predominantly with Diarrhea from Celiac Disease. Clin Lab. 2020, 1; 66 (3). doi: 10.7754/Clin.Lab.2020.191215. PMID: 32162872.
Mohan H, Ramesh N, Mortazavi S, Le A, Iwakura H, Unniappan S. Nutrients differentially regulate nucleobindin-2/nesfatin-1 in vitro in cultured stomach ghrelinoma (MGN3-1) cells and in vivo in male mice. PloS one. 2014; 9 (12): e115102.
Kentish SJ, Li H, Frisby CL, Page AJ. Nesfatin-1 modulates murine gastric vagal afferent mechano sensitivity in a nutritional state dependent manner. Peptides. 2017; 89:35-41.
Hofmann T, Ahnis A, Elbelt U, Rose M, Klapp BF, Stengel A. NUCB2/nesfatin-1 is associated with elevated levels of anxiety in anorexia nervosa. PLoS One. 2015 Jul 10;10(7): e0132058.
Hofmann T, Elbelt U, Ahnis A, Rose M, Klapp BF, Stengel A. Sex-specific regulation of NUCB2/nesfatin-1: Differential implication in anxiety in obese men and women. Psychoneuroendocrinology. 2015 Oct 1; 60:130-7.
Li J, Nishida M, Kaimoto K, Asakawa A, Chaolu H, Cheng K, Li Y, Terashi M, Koyama KI, Amitani H, Amitani H, et al: Effects of aging on the plasma levels of nesfatin‑1 and adiponectin. Biomed Rep 2014, 2: 152-156.
Li QC, Wang HY, Chen X, et al: Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul Pept. 2010, 159:72–77.
Massironi S, Branchi F, Rossi RE, Fraquelli M, Elli L, Bardella MT, Cavalcoli F, Conte D. Hepatic hemangioma in celiac patients: data from a large consecutive series. Gastroenterol Res Pract. 2015; 2015:749235. doi: 10.1155/2015/749235. Epub 2015 Jan 12. PMID: 25649925; PMCID: PMC4306374.
Taha Y, Raab Y, Larsson A, Carlson M, Lööf L, Gerdin B, Thörn M. Vascular endothelial growth factor (VEGF)--a possible mediator of inflammation and mucosal permeability in patients with collagenous colitis. Dig Dis Sci. 2004; 49(1):109-15. doi: 10.1023/b: ddas.0000011611. 92440.f2. PMID: 14992444.
Wierdsma, N.J.; Van Bokhorst-de van der Schueren, M.A.E.; Berkenpas, M.; Mulder, C.J.J.; Van Bodegraven, A.A. Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients. Nutrients 2013, 5, 3975-3992. https:// doi.org/ 10.3390/nu5103975.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)
This work is licensed under a Creative Commons Attribution 4.0 International License.
